Maternal flaxseed diet during pregnancy or lactation increases female rat offspring's susceptibility to carcinogen-induced mammary tumorigenesis

G Khan, P Penttinen, A Cabanes, A Foxworth… - Reproductive …, 2007 - Elsevier
Flaxseed contains several dietary components that have been linked to low breast cancer
risk; ie, n-3 polyunsaturated fatty acids (PUFAs), lignans and fiber, but it also contains …

Exposure to flaxseed or its lignan component during different developmental stages influences rat mammary gland structures

JCL Tou, LU Thompson - Carcinogenesis, 1999 - academic.oup.com
Reduction of the highly proliferative terminal end bud (TEB) structures in the developing
mammary gland by differentiation to alveolar buds (ABs) and lobules has been suggested to …

Exposure to flaxseed or its purified lignan during suckling inhibits chemically induced rat mammary tumorigenesis

J Chen, KP Tan, WE Ward… - … Biology and Medicine, 2003 - journals.sagepub.com
Previous studies have shown that feeding flaxseed (FS) or its lignan secoisolariciresinol
diglucoside (SDG) to rat dams during lactation enhances the differentiation of rat mammary …

Maternal dietary exposure to fiber during pregnancy and mammary tumorigenesis among rat offspring

B Yu, G Khan, A Foxworth, K Huang… - … journal of cancer, 2006 - Wiley Online Library
Maternal diet during pregnancy has been proposed to modify female offspring's later
susceptibility to develop breast cancer; however, most of the dietary factors identified thus far …

Exposure to flaxseed or purified lignan during lactation influences rat mammary gland structures

WE Ward, FO Jiang, LU Thompson - Nutrition and cancer, 2000 - Taylor & Francis
Previous investigation demonstrated that feeding a 10% flaxseed (10F) diet during
pregnancy and lactation enhanced the differentiation of highly proliferative terminal end bud …

[HTML][HTML] Interactive effects of Flax seeds and tamoxifen on human breast cancer

LU Thompson, J Chen, E Hui… - Proc 60th Flax Institute …, 2004 - goldenvalleyflax.com
Flaxseed is the richest source of the phytoestrogen lignans, containing 75-800 times higher
concentration than other plant foods in the vegetarian diet. It is also a very rich source of a …

Dietary modulation of pregnancy estrogen levels and breast cancer risk among female rat offspring

L Hilakivi-Clarke, E Cho, A Cabanes, S DeAssis… - Clinical cancer …, 2002 - AACR
Purpose: Against the hypothesis that high estrogen levels in utero increase the risk of
developing breast cancer in later life are data showing that pregnancy estrogen levels are …

Consumption of flaxseed, a rich source of lignans, is associated with reduced breast cancer risk

EC Lowcock, M Cotterchio, BA Boucher - Cancer Causes & Control, 2013 - Springer
Purpose To investigate the association between intake of flaxseed—the richest source of
dietary lignans (a class of phytoestrogens)—and breast cancer risk. Methods A food …

Mammary gland morphogenesis is enhanced by exposure to flaxseed or its major lignan during suckling in rats

KP Tan, J Chen, WE Ward… - … Biology and Medicine, 2004 - journals.sagepub.com
The exposure of rats to 10% flaxseed (FS) or an equivalent level of its major lignan,
secoisolariciresinol diglucoside (SDG), during suckling enhances mammary gland …

Effect of flaxseed consumption on urinary levels of estrogen metabolites in postmenopausal women

SR Sturgeon, SL Volpe, E Puleo… - Nutrition and …, 2010 - Taylor & Francis
Flaxseed is a rich source of dietary lignans. It has been hypothesized that lignans may
decrease breast cancer risk through modulation of endogenous hormone levels. The aim of …