Disorders of spermatogenesis: perspectives for novel genetic diagnostics after 20 years of unchanged routine
F Tüttelmann, C Ruckert, A Röpke - Medizinische Genetik, 2018 - degruyter.com
Infertility is a common condition estimated to affect 10–15% of couples. The clinical causes
are attributed in equal parts to the male and female partners. Diagnosing male infertility …
are attributed in equal parts to the male and female partners. Diagnosing male infertility …
Developmental and genetic disorders in spermatogenesis
T Diemer, C Desjardins - Human Reproduction Update, 1999 - academic.oup.com
The most common cause of male infertility is idiopathic. Fresh insights based on genetic and
molecular analysis of the human genome permit classification of formerly unexplained …
molecular analysis of the human genome permit classification of formerly unexplained …
Sequence analysis of 37 candidate genes for male infertility: challenges in variant assessment and validating genes
TF Araujo, C Friedrich, CHP Grangeiro, LR Martelli… - …, 2020 - Wiley Online Library
Background The routine genetic analysis for diagnosing male infertility has not changed
over the last twenty years, and currently available tests can only determine the etiology of …
over the last twenty years, and currently available tests can only determine the etiology of …
Gene polymorphisms/mutations relevant to abnormal spermatogenesis
F Nuti, C Krausz - Reproductive biomedicine online, 2008 - Elsevier
Despite the identification of an increasing number of candidate genes involved in
spermatogenesis, the armamentarium of diagnostic genetic tests in male infertility remains …
spermatogenesis, the armamentarium of diagnostic genetic tests in male infertility remains …
Genetic evaluation of patients with non-syndromic male infertility
Purpose This review provides an update on the genetics of male infertility with emphasis on
the current state of research, the genetic disorders that can lead to non-syndromic male …
the current state of research, the genetic disorders that can lead to non-syndromic male …
Testing for genetic contributions to infertility: potential clinical impact
Introduction: Male infertility affects about 7% of the general male population, and it is a
multifactorial, polygenic pathological condition. Known genetic factors, accounting for about …
multifactorial, polygenic pathological condition. Known genetic factors, accounting for about …
A search for molecular mechanisms underlying male idiopathic infertility
A Bracke, K Peeters, U Punjabi, D Hoogewijs… - Reproductive …, 2018 - Elsevier
Infertility affects approximately 15% of the couples wanting to conceive. In 30− 40% of the
cases the aetiology of male infertility remains unknown and is called idiopathic male …
cases the aetiology of male infertility remains unknown and is called idiopathic male …
Role of genetics and epigenetics in male infertility
S Gunes, SC Esteves - Andrologia, 2021 - Wiley Online Library
Male infertility is a complex condition with a strong genetic and epigenetic background. This
review discusses the importance of genetic and epigenetic factors in the pathophysiology of …
review discusses the importance of genetic and epigenetic factors in the pathophysiology of …
Genetic causes of male infertility
Genetic causes account for 10–15% of severe male infertility, including chromosomal
aberrations and single gene mutations. Natural selection prevents the transmission of …
aberrations and single gene mutations. Natural selection prevents the transmission of …
Disease gene discovery in male infertility: past, present and future
Identifying the genes causing male infertility is important to increase our biological
understanding as well as the diagnostic yield and clinical relevance of genetic testing in this …
understanding as well as the diagnostic yield and clinical relevance of genetic testing in this …