Background Depression is a common mental health condition with considerable negative
impact on health and well-being. Although antidepressants are recommended as first-line …

Approximately half of the tens of millions of people currently taking antidepressants will
experience withdrawal symptoms when they try to reduce or come off them. Nearly half of …

Introduction Prescription rates for antidepressants (ADs) are high and continue to increase,
despite evidence of significant adverse effects, including withdrawal symptoms, and …

Objective: The purpose of this review is to summarize lessons learned from, and limitations
of, the Sequenced Treatment Alternatives to Relieve Depression (STAR* D) trial, focusing on …

Background The World Health Organization recommends that treatment of depression in low
and middle-income countries with a scarcity of psychiatrists could be done in primary care …

Background: Stopping antidepressants commonly causes withdrawal symptoms, which can
be severe and long-lasting. National Institute for Health and Care Excellence (NICE) …

OBJECTIVE: The Improving Mood-Promoting Access to Collaborative Treatment (IMPACT)
trial [randomized controlled trial (RCT)] found that collaborative care management of …

Objective Reanalyse the patient-level data set of the Sequenced Treatment Alternatives to
Relieve Depression (STAR* D) study with fidelity to the original research protocol and …

The ideal medication for depression would be a drug with a high level of effectiveness and a
low side-effect profile; until now, however, there has been little evidence to support 1 …

Background There is concern internationally about increasing antidepressant use. Most
antidepressants are prescribed in general practice. The aim of this study was to compare …