Discontinuation of drug intake in cocaine abusers commonly produces a variety of adverse
withdrawal symptoms among which anxiety and depression-related behavior are prevailing …

Craving elicited by drug-associated cues intensifies across protracted drug abstinence–a
phenomenon termed “incubation of craving”–and drug-craving in human addicts correlates …

Preclinical models of stress-induced relapse to drug use have shown that the dysregulation
of glutamatergic transmission within the nucleus accumbens (NA) contributes notably to the …

This chapter will describe the behavioral characteristics of cocaine self-administration and
highlight the procedures that have been used in experimental studies to measure its …

The nucleus accumbens core (NAc) is important for integrating and providing information to
downstream areas about the timing and value of anticipated reward. Although NAc is one of …

Background Cocaine addiction is associated with altered sensitivity to natural reinforcers
and intense drug craving. However, previous findings on reward-related responses were …

The relative impact of chronic vs acute cocaine on dependence-related variability in reward
processing in cocaine-dependent individuals (CD) is not well understood, despite the …

Background Prominent neurobiological theories of addiction posit a central role for aberrant
mesolimbic dopamine release but disagree as to whether repeated drug experience blunts …

The recent escalation of cocaine abuse has increased awareness of the need to understand
the behavioral effects of cocaine and the determinants of those effects. Cocaine alters both …

Anhedonia is a major symptom of cocaine withdrawal, whereas euphoria characterizes the
effects of acute administration of this drug in humans. These mood states can be measured …