The 5‐HT2C receptor has been implicated in mood and eating disorders. In general, it is
accepted that 5‐HT2C receptor agonists increase anxiety behaviours and induce …

Background: Desensitization and blockade of 5-HT2C receptors (5-HT2CR) have long been
thought to be central in the therapeutic action of antidepressant drugs. However, besides …

5-HT2C receptors are predominantly localised in the brain and their dysregulation may
contribute to particular symptoms of anxiety and depression. The marked affinity of several …

Central serotonin (5‐hydroxytryptamine, 5‐HT) systems have been implicated in the
pathophysiology and treatment of anxiety disorders, which are among the world's most …

The present overview explores the role of the 5‐HT2 receptor subtypes (5‐HT2A, 5‐HT2B,
and 5HT2C) in anxiety models in animals with clinical consideration for the development of …

Anxiety disorders are the most common psychiatric disorders. Typical medications used to
treat patients are benzodiazepines or antidepressants that target serotonin (5-HT) activity …

5-HT4 receptors control brain physiological functions such as learning and memory, feeding
and mood behaviour as well as gastro-intestinal transit. 5-HT4 receptors are one of the 5-HT …

HT1A receptors play a critical role in the pathophysiology of anxiety and depression as well
as in the mode of action of anxiolytic and antidepressant drugs. Mice with a targeted …

Animal experimental studies suggest that 5-HT4 receptor activation holds promise as a
novel target for the treatment of depression and cognitive impairment. 5-HT4 receptors are …

Mental disorders, such as depression and anxiety, pose both medical and social challenges.
The clinical efficacy of current antidepressant/anxiolytic therapies is unsatisfactory; both …