[引用][C] Absence of EGFR mutation in the kinase domain in common human cancers besides non‐small cell lung cancer

JW Lee, YH Soung, SY Kim, WS Park… - … Journal of Cancer, 2005 - Wiley Online Library
The epidermal growth factor receptor (EGFR), a receptor protein tyrosine kinase, contributes
to a number of processes in tumor survival and growth activity, thus making it a promising …
被引用次数：107 相关文章 所有 7 个版本

EGFR mutation and response of lung cancer to gefitinib

S Toyooka, K Kiura, T Mitsudomi - N Engl J Med, 2005 - researchgate.net
to the editor: Kobayashi et al.(Feb. 24 issue) 1 report that a second mutation in the gene
encoding the epidermal growth factor receptor (EGFR), one resulting in a threonine-to …
被引用次数：158 相关文章 所有 8 个版本
[PDF] academia.edu

[PDF][PDF] Common EGFR mutations conferring sensitivity to gefitinib in lung adenocarcinoma are not prevalent in human malignant mesothelioma

JF Cortese, AL Gowda, A Wali, JF Eliason… - International journal of …, 2006 - academia.edu
Dear Sir, Gefitinib (Iressa) is a small-molecule inhibitor of the epidermal growth factor
receptor (EGFR) that produces markedly favorable responses in a subset of patients with …
被引用次数：66 相关文章 所有 7 个版本
[HTML] nejm.org

Activating mutations in the epidermal growth factor receptor underlying responsiveness of non–small-cell lung cancer to gefitinib

TJ Lynch, DW Bell, R Sordella… - … England Journal of …, 2004 - Mass Medical Soc
Background Most patients with non–small-cell lung cancer have no response to the tyrosine
kinase inhibitor gefitinib, which targets the epidermal growth factor receptor (EGFR) …
被引用次数：14037 相关文章 所有 10 个版本

Phase II study of the efficacy of gefitinib in patients with non-small cell lung cancer with the EGFR mutations

N Sunaga, N Yanagitani, K Kaira… - Journal of Clinical …, 2006 - ascopubs.org
7183 Purpose: Recent studies have indicated that the mutations of epidermal growth factor
receptor (EGFR) were associated with sensitivity of non-small cell lung cancer (NSCLC) to …
被引用次数：27 相关文章 所有 2 个版本

EGFR point mutation confers resistance to gefitinib in a patient with non-small-cell lung cancer

G Giaccone - Nature clinical practice Oncology, 2005 - nature.com
Background Chemotherapy is a partially effective treatment for advanced non-small-cell
lung cancer (NSCLC), the leading cause of cancer mortality in the US. The epidermal …
被引用次数：30 相关文章 所有 5 个版本

Mutation in the tyrosine kinase domain of epidermal growth factor receptor is a predictive and prognostic factor for gefitinib treatment in patients with non–small cell …

TY Chou, CH Chiu, LH Li, CY Hsiao, CY Tzen… - Clinical cancer …, 2005 - AACR
Purpose: Mutations in epidermal growth factor receptor (EGFR) can be used to predict the
tumor response of patients receiving gefitinib for non–small cell lung cancer (NSCLC). We …
被引用次数：360 相关文章 所有 9 个版本

Biological and clinical implications of EGFR mutations in lung cancer

T Mitsudomi, T Kosaka, Y Yatabe - International journal of clinical …, 2006 - Springer
Background Patients with non-small-cell lung cancer sometimes show a dramatic clinical
response to gefitinib or erlotinib, small-molecule tyrosine kinase inhibitors (TKI) specific for …
被引用次数：286 相关文章 所有 11 个版本

Double mutation and gene copy number of EGFR in gefitinib refractory non-small-cell lung cancer

M Tokumo, S Toyooka, S Ichihara, K Ohashi… - Lung cancer, 2006 - Elsevier
Mutations of the epidermal growth factor receptor (EGFR) gene have been reported in non-
small-cell lung cancer (NSCLC), especially in patients with adenocarcinoma and never …
被引用次数：73 相关文章 所有 9 个版本

High frequency of epidermal growth factor receptor mutations with complex patterns in non–small cell lung cancers related to gefitinib responsiveness in Taiwan

SF Huang, HP Liu, LH Li, YC Ku, YN Fu, HY Tsai… - Clinical Cancer …, 2004 - AACR
Purpose: Epidermal growth factor receptor (EGFR) mutations related to gefitinib
responsiveness in non–small cell lung cancer have been found recently. Detection of EGFR …
被引用次数：715 相关文章 所有 14 个版本