The discovery of new drugs often accompanies the need for improved drug delivery vehicles
that tackle common problems associated with drug solubility, stability, and biodistribution …

Amphiphilic Janus dendrimers (JDs), synthetic alternatives to lipids, have the potential to
expand the scope of nanocarrier delivery systems. JDs self-assemble into vesicles called …

Amphiphilic Janus dendrimers (JDs) are constructed from hydrophobic and hydrophilic
dendrons, providing a synthetic alternative to lipids in drug delivery applications. These JDs …

Among the current selection of modern drugs, most are hydrophobic causing insolubility in
the bloodstream. In order to improve solubility, vesicles similar to a cell's lipid bilayer can be …

Nucleic acid therapeutics are becoming an important drug modality, offering the unique
opportunity to address “undruggable” targets, respond rapidly to evolving pathogens, and …

Small interfering RNA (siRNA) therapeutics hold great promise to treat a variety of diseases,
as long as they can be delivered safely and effectively into cells. Dendrimers are appealing …

Targeted and efficient delivery of nucleic acids with viral and synthetic vectors is the key step
of genetic nanomedicine. The four-component lipid nanoparticle synthetic delivery systems …

Conspectus Dendrimers, a special family of polymers, are particularly promising materials
for various biomedical applications by virtue of their well-defined dendritic structure and …

Viral and synthetic vectors for delivery of nucleic acids impacted genetic nanomedicine by
aiding the rapid development of the extraordinarily efficient Covid-19 vaccines. Access to …

Efficient viral or nonviral delivery of nucleic acids is the key step of genetic nanomedicine.
Both viral and synthetic vectors have been successfully employed for genetic delivery with …