Inflammation plays a major role in the onset and progression of many diseases related to the
respiratory system. Cysteinyl leukotrienes, the products of 5-LOX are a potent …

Eicosanoid pathways play a crucial role in the progression and resolution of inflammation.
NSAIDs act as anti-inflammatory agents by inhibiting both the isoforms of cyclooxygenases …

Inflammation is a self-protective response to start the healing process. An anti-inflammatory
target worth developing are lipoxygenase inhibitors, which have been studied for several …

Lipoxygenase (5-LO) is one of the key enzymes involved in the production of pro-
inflammatory mediators, such as leukotriene B4 and cysteinyl leukotrienes. Inhibition of 5-LO …

The leaves, flowers, seeds, and bark of the Nyctanthes arbor-tristis Linn plant have been
pharmacologically evaluated to signify the medicinal importance traditionally described for …

Inflammation is caused by a cascade of events, one of which is the metabolism of
arachidonic acid, that begins with oxidation by the enzyme 5-lipoxygenase. 5-Lipoxygenase …

Abstract Introduction Compound D and DMPBD are compounds extracted from Plai or
Zingiber cassumunar Roxb., which have antiasthmatic properties. Thai herbal …

Lipoxygenases (LOX) are enzymes that catalyze polyunsaturated fatty acid peroxidation and
have a non-heme iron atom located in their active site. They are implicated in the …

Natural products acquire massive structural and chemical diversity, which cannot be
coordinated by any synthetic libraries for small molecules and they are continuing to inspire …

The three primary enzymes COX (cyclooxygenase), LOX (lipoxygenase) and CYT-P450
(cytochrome P450), which are part of the arachidonic inflammatory pathway, play crucial role …