Association of prehospitalization aspirin therapy and acute lung injury: results of a multicenter international observational study of at-risk patients

DJ Kor, J Erlich, MN Gong, M Malinchoc… - Critical care …, 2011 - journals.lww.com
Objective: To evaluate the association between prehospitalization aspirin therapy and
incident acute lung injury in a heterogeneous cohort of at-risk medical patients. Design: This …

Prehospital aspirin use is associated with reduced risk of acute respiratory distress syndrome in critically ill patients: a propensity-adjusted analysis

W Chen, DR Janz, JA Bastarache, AK May… - Critical care …, 2015 - journals.lww.com
Objectives: Platelet activation plays an active role in the pathogenesis of acute respiratory
distress syndrome. In our prior study of 575 patients at high risk for acute respiratory distress …

Effect of aspirin on development of ARDS in at-risk patients presenting to the emergency department: the LIPS-A randomized clinical trial

DJ Kor, RE Carter, PK Park, E Festic… - Jama, 2016 - jamanetwork.com
Importance Management of acute respiratory distress syndrome (ARDS) remains largely
supportive. Whether early intervention can prevent development of ARDS remains unclear …

[HTML][HTML] Association between aspirin therapy and the outcome in critically ill patients: a nested cohort study

SA Al Harbi, HM Tamim, HM Al-Dorzi, M Sadat… - BMC Pharmacology and …, 2016 - Springer
Background Antiplatelet therapy may attenuate the undesirable effects of platelets on the
inflammatory cascades in critical illness. The objective of this study was to evaluate the …

Lung Injury Prevention with Aspirin (LIPS-A): a protocol for a multicentre randomised clinical trial in medical patients at high risk of acute lung injury

DJ Kor, DS Talmor, VM Banner-Goodspeed… - BMJ open, 2012 - bmjopen.bmj.com
Introduction Acute lung injury (ALI) is a devastating condition that places a heavy burden on
public health resources. Although the need for effective ALI prevention strategies is …

Prehospitalization antiplatelet therapy is associated with a reduced incidence of acute lung injury: a population-based cohort study

JM Erlich, DS Talmor, R Cartin-Ceba, O Gajic, DJ Kor - Chest, 2011 - Elsevier
Background Acute lung injury (ALI) is a potentially fatal lung disease with few treatment
options. Platelet activation is a key component of ALI pathophysiology and may provide an …

Prehospital use of aspirin rarely is associated with adverse events

D Quan, F LoVecchio, B Clark… - Prehospital and disaster …, 2004 - cambridge.org
Introduction: Aspirin is commonly administered for acute coronary syndromes in the
prehospital setting. Few studies have addressed the incidence of adverse effects associated …

[HTML][HTML] The association of aspirin use with severity of acute exacerbation of chronic obstructive pulmonary disease: a retrospective cohort study

T Goto, MK Faridi, CA Camargo… - NPJ primary care …, 2018 - nature.com
Little is known about the effect of long-term aspirin use on acute severity of COPD. We
hypothesized that, in patients hospitalized for acute exacerbation of COPD (AECOPD), long …

Quantifying the effects of prior acetyl-salicylic acid on sepsis-related deaths: an individual patient data meta-analysis using propensity matching

J Trauer, S Muhi, ES McBryde, SA Al Harbi… - Critical care …, 2017 - journals.lww.com
Objective: The primary objective was to conduct a meta-analysis on published observational
cohort data describing the association between acetyl-salicylic acid (aspirin) use prior to the …

Prevention or treatment of ARDS with aspirin: a review of preclinical models and meta-analysis of clinical studies

BA Panka, HJ de Grooth, AME Spoelstra-de Man… - Shock, 2017 - journals.lww.com
Background: The acute respiratory distress syndrome (ARDS) is a life-threating disorder that
contributes significantly to critical illness. No specific pharmacological interventions directed …