Rationale: Acute respiratory distress syndrome (ARDS) is a devastating illness with limited
therapeutic options. A better understanding of early biochemical and immunological events …

BACKGROUND: ARDS is characterized by decreased functional residual capacity (FRC),
heterogeneous lung injury, and severe hypoxemia. Tidal ventilation is preferentially …

Study objectives This study was carried out to determine the efficacy of and dose-response
relationships to inhaled aerosolized prostacyclin (IAP), when used as a selective pulmonary …

Background Major adverse cardiac events (MACEs) are a common cause of death after non-
cardiac surgery. Despite evidence for the benefit of aspirin for secondary prevention, it is …

Objective: Mortality associated with acute lung injury remains high. Early identification of
acute lung injury prior to onset of respiratory failure may provide a therapeutic window to …

CLINICAL VIGNETTE A 36-year-old graphic designer was referred for difficult-tocontrol
asthma, chronic sinusitis, and a history of reacting to nonsteroidal anti-inflammatory drugs …

Objectives. Low‐dose aspirin given for secondary prevention of cardiovascular disease is
frequently withdrawn prior to surgical or diagnostic procedures to reduce bleeding …

Antiplatelet therapy is an attractive treatment option for critically ill patients. However, more
evidence on the benefit of this therapy is required. We searched the PubMed and Embase …

Background Acute lung injury (ALI) is an example of a critical care syndrome with limited
treatment options once the condition is fully established. Despite improved understanding of …

Background: The efficacy and safety of aspirin for primary prevention of cardiovascular
disease (CVD) remain debatable. Objectives: The purpose of this study was to examine the …