There is accumulating evidence that substance P released from peripheral sensory neurons
participates in inflammatory and neuropathic pain. In this study it was investigated the ability …

The neuropeptide Substance P (SP), that has a high affinity for the neurokinin 1 (NK1)
receptor, is involved in modulation of pain transmission. Although SP is thought to have …

Although many studies have demonstrated a role for substance P in pain, there have been
conflicting reports implicating the involvement of substance P in neuropathic pain models. In …

Substance P (SP) binds to the NK-1 receptor and has been implicated in the transmission of
pain as well as in physiological responses such as salivary gland secretion and neurogenic …

The effects of ip administration of the nitric oxide synthase inhibitor NG‐nitro‐L‐arginine
methylester (L‐NAME) and its inactive isomer, D‐NAME, were tested in two nociceptive …

Substance P and the related tachykinin peptides are involved in inflammatory processes
and in the transmission of sensory nociceptive information. In this article we review the …

Background: Although substance P (SP) is an important primary afferent modulator in
nociceptive processes, it is unclear whether SP regulates its own release from primary …

Abstract CP-96,345, a potent non-peptide antagonist of the substance P (SP) receptor,
inhibited SP-, neurokinin A (NKA)-and neurokinin B-induced plasma extravasation in guinea …

The undecapeptide substance P is expressed by primary afferent neurons where it is
considered to be a cotransmitter of other peptides and glutamate. Since it is predominantly …

Chronic inflammatory conditions are associated with an upregulation of both substance P
(SP) and neurokinin‐1 (NK‐1) receptors in the dorsal spinal cord. These receptors have …