Septic shock results from excessive stimulation of host immune cells, particularly monocytes
and macrophages, by lipopolysaccharide (LPS) released from gram-negative bacteria …

We have tested whether tetracyclines (TETs) are able to protect mice from
lipopolysaccharide (LPS)-induced shock, a cytokine-mediated inflammatory reaction. Mice …

Experimental and clinical studies in sepsis indicate that antibiotic therapy may induce the
release of endotoxin (LPS) from the outer membrane of gram-negative bacteria and …

Background: Sepsis may lead to the suppression of stimulated cytokine release after Gram‐
negative stimuli, correlating with a fatal outcome. Treatment of sepsis includes adequate …

Doxycycline is used to treat infective diseases because of its broadspectrum efficacy. High
dose administration (100 or 200 mg/day) is often responsible for development of bacterial …

Recent reports have shown that antibiotics such as macrolide, aminoglycoside, and
tetracyclines have immunomodulatory effects in addition to essential antibiotic effects. These …

The interactions of lipopolyamines, a class of structurally unique compounds currently being
used as transfection (lipofection) agents, with lipopolysaccharide (LPS) have been …

Minocycline is a tetracycline derivative that has beneficial effects in noninfectious forms of
arthritis and dermatitis. To investigate whether this effect may be attributed to interference …

Sepsis precipitates a systemic inflammatory stimulus that causes systemic release of
cytokines and sequestration of polymorphonuclear neutrophils, resulting in degranulation of …

Different antibiotic treatments may affect the survival and physiological responses of Balb/c
mice following cecal ligation and puncture (CLP). The broad spectrum imipenem (IMP) was …