Background Gallstone disease (GD) is common but remains asymptomatic in most cases.
However, gallstones can lead to complications like choledocholithiasis or gallbladder …

Cholesterol cholelithiasis is one of the most common gastroenterological diseases in
Western countries. It is a polygenic disease resulting from disturbed biliary cholesterol …

Background Gallstone disease is associated with p. D19H of ABCG8 as well as alterations
of cholesterol and bile acid metabolism. However, molecular mechanisms have not been …

Gallstones Disease (GSD) is one of the most common digestive diseases requiring
hospitalization and surgical procedures in the world. GSD has a high prevalence in …

The number of gallstone patients is increasing in ageing populations with a high prevalence
of metabolic syndrome and obesity. Recently variants of hepatic ATP binding cassette …

Objectives: The objectives for this study were to examine the associations between
metabolic biomarkers of obesity including insulin resistance, vascular dysfunction, systemic …

Background: Gallbladder cancer (GBC) usually arises against the background of gallstone
disease, which may be causatively related to supersaturation of cholesterol in bile. An …

Gallstone disease, a risk factor for biliary cancer, has a strong heritable component, but the
underlying genes are largely unknown. To test the hypothesis that ABCG8 (adenosine …

Gallbladder cancer (GBC) is a violent neoplasm associated with late diagnosis,
unsatisfactory treatment, and poor prognosis. The disease shows complex interplay …

Gallbladder cancer (GBC) is a multifactorial disease with complex interplay between
multiple genetic variants. We performed Classification and Regression Tree Analysis …