Dynamic binding of transcription factors (TFs) to regulatory elements controls transcriptional
states throughout organism development. Epigenetics modifications, such as DNA …

Transcription factors (TFs) and epigenetic modifications play crucial roles in the regulation of
gene expression, and correlations between the two types of factors have been discovered …

DNA methylation, which occurs predominantly at CpG dinucleotides, is a potent epigenetic
repressor of transcription. Because DNA methylation is reversible, there is much interest in …

Epigenetic DNA modification impacts gene expression, but the underlying molecular
mechanisms are only partly understood. Adding a methyl group to a cytosine base locally …

Although DNA methylation is commonly invoked as a mechanism for transcriptional
repression, the extent to which it actively silences transcription factor (TF) occupancy sites in …

Although DNA modifications play an important role in gene regulation, the underlying
mechanisms remain elusive. We developed EpiSELEX-seq to probe the sensitivity of …

Background DNA methylation in promoters is closely linked to downstream gene repression.
However, whether DNA methylation is a cause or a consequence of gene repression …

Distal regulatory elements, including enhancers, play a critical role in regulating gene
activity. Transcription factor binding to these elements correlates with Low Methylated …

Cytosine methylation efficiently silences CpG-rich regulatory regions of genes and repeats
in mammalian genomes. To what extent this entails direct inhibition of transcription factor …

Methylation of CpG (cytosine-phosphate-guanine) dinucleotides is a common epigenetic
mark that influences gene expression. The effects of methylation on transcription factor (TF) …