Objective Our objective was to investigate the effect of single nucleotide polymorphisms
(SNPs) in the P‐glycoprotein MDR1 gene on vincristine pharmacokinetics and side effects in …

9526 Background: Vincristine plays a key role in the treatment of acute lymphoblastic
leukemia (ALL) in children. Constipation and peripheral or central neurotoxicity's are the …

Over the past four decades, the treatment of ALL among children has improved dramatically.
Despite this success, drug resistance and treatment failure due to treatment-related toxicity …

Early response to therapy as determined by Day 8 prednisolone response (PR) and minimal
residual disease (MRD) are highly predictive of risk of relapse in childhood ALL. They are …

The significance of genetic background in childhood acute lymphoblastic leukemia (ALL) is
not well understood. Polymorphisms of genes encoding for xenobiotics and drug …

Introduction: Acute lymphoblastic leukemia (ALL) is the major pediatric malignancy of all
childhood cancers. P glycoprotein (P-gp) is encoded by multidrug resistance 1 (MDR1) …

Abstract P-glycoprotein (P-gp), a membrane transporter encoded by multidrug resistance 1
(MDR1) gene, influences pharmacokinetics of anticancer drugs and contributes to multidrug …

Background: Acute lymphoblastic leukemia (ALL) is the most common malignancy in
children, though the etiology of the leukemia is poorly understood, both genetic and …

Background Acute lymphoblastic leukemia (ALL) is the most common malignancy in
children, though the etiology of the leukemia is poorly understood, both genetic and …

Background: Multidrug resistance is the main reason of unsuccessful chemotherapy. The
most important cause of drug resistance is ATP dependent pumps such as MDR1 that …