In vitro genotoxicity of PAH mixtures and organic extract from urban air particles: Part I: Acellular assay

B Binkova, J Topinka, RJ Sram, O Sevastyanova… - Mutation Research …, 2007 - Elsevier
Acellular assay of calf thymus DNA±rat liver microsomal S9 fraction coupled with 32P-
postlabelling was used to study the genotoxic potential of organic compounds bound onto …

[HTML][HTML] The development of a cell-based model for the assessment of carcinogenic potential upon long-term PM2. 5 exposure

S Chen, D Li, H Zhang, D Yu, R Chen, B Zhang… - Environment …, 2019 - Elsevier
To assess the carcinogenic potential of PM2. 5 exposure, we developed a cell-based
experimental protocol to examine the cell transformation activity of PM2. 5 samples from …

Exposure to atmospheric particulate matter-bound polycyclic aromatic hydrocarbons and their health effects: a review

L Yang, H Zhang, X Zhang, W Xing, Y Wang… - International journal of …, 2021 - mdpi.com
Particulate matter (PM) is a major factor contributing to air quality deterioration that enters
the atmosphere as a consequence of various natural and anthropogenic activities. In PM …

Comparative mechanisms of PAH toxicity by benzo [a] pyrene and dibenzo [def, p] chrysene in primary human bronchial epithelial cells cultured at air-liquid interface

Y Chang, LK Siddens, LK Heine, DA Sampson… - Toxicology and applied …, 2019 - Elsevier
Current assumption for assessing carcinogenic risk of polycyclic aromatic hydrocarbons
(PAHs) is that they function through a common mechanism of action; however, recent …

DNA binding of polycyclic aromatic hydrocarbons in a human bronchial epithelial cell line treated with diesel and gasoline particulate extracts and benzo[a]pyrene

SK Pohjola, M Lappi, M Honkanen, L Rantanen… - …, 2003 - academic.oup.com
Particulate matter of vehicle exhaust is known to contain carcinogenic compounds such as
polycyclic aromatic hydrocarbons (PAH) and is suggested to increase lung cancer risk in …

Tumors and DNA adducts in mice exposed to benzo [a] pyrene and coal tars: implications for risk assessment.

LS Goldstein, EH Weyand, S Safe… - Environmental …, 1998 - ehp.niehs.nih.gov
Current methods to estimate the quantitative cancer risk of complex mixtures of polycyclic
aromatic hydrocarbons (PAH) such as coal tar assume that overall potency can be derived …

[HTML][HTML] Chemical fingerprints and implicated cancer risks of Polycyclic aromatic hydrocarbons (PAHs) from fine particulate matter deposited in human lungs

X Zhang, S Leng, M Qiu, Y Ding, L Zhao, N Ma… - Environment …, 2023 - Elsevier
Exposure to fine particles (PM 2.5) and associated PAHs are frequently linked with lung
cancer, which makes the understanding of their occurrence and health risk in human lungs …

The genotoxic effect of carcinogenic PAHs, their artificial and environmental mixtures (EOM) on human diploid lung fibroblasts

B Binková, RJ Šrám - Mutation Research/Fundamental and Molecular …, 2004 - Elsevier
The aim of this study was to investigate the genotoxic effect of single carcinogenic polycyclic
aromatic hydrocarbons (c-PAHs), as well as their binary and artificial mixtures containing c …

[HTML][HTML] Determination of whole mixture-based potency factors for cancer risk assessment of complex environmental mixtures by in vitro testing of standard reference …

MF de Oliveira Galvão, I Sadiktsis, TM Pedro… - Environment …, 2022 - Elsevier
Whole mixture-based testing using in vitro new approach methodologies (NAMs) has been
suggested to facilitate the hazard and risk assessment of complex environmental mixtures …

Carcinogenic polycyclic aromatic hydrocarbons

A Luch, WM Baird - Comprehensive toxicology, 2010 - hero.epa.gov
Polycyclic aromatic hydrocarbons (PAHs) are formed upon incomplete combustion of
organic matter. Due to the abundant use of fossil energy sources, PAHs are readily …