The loss of ovarian follicles through atresia, which accounts for greater than 99% of
postnatal female germ cell depletion, is mediated through apoptotic cell death. Although …

Oocyte loss, either directly through attrition (germ cell death) or indirectly through follicular
atresia (somatic or granulosa cell death), is a fundamental event associated with defining …

Studies were conducted to evaluate the susceptibility of avian ovarian granulosa cells to
apoptosis when incubated in vitro and to relate this relative susceptibility to both the stage of …

Recent data support a role for apoptosis, under tight regulatory control by bcl-2, oxidative
stress response, tumor suppressor, and CASP gene family members, in mediating …

Members of the Bcl-2 family serve as central checkpoints for cell death regulation, and
overexpression of Bcl-2 is known to inhibit apoptosis in many cell types. To determine …

We have generated transgenic mice overexpressing Bcl-2, an apoptosis suppression
protein, in ovarian cells using the inhibit-alpha gene promoter/enhancer. Ovarian apoptotic …

We have reported that members of the bcl-2 gene family are expressed and gonadotropin
regulated in ovarian granulosa cells during follicular maturation and atresia. Because Bcl-2 …

To investigate the relationship between apoptosis and the Bcl-2/Bax system in the human
corpus luteum (CL), the frequency of apoptosis and expression of Bcl-2 and Bax were …

Since the cloning of the bcl-2 gene in 1985, considerable progress has been made in
elucidating the function of Bcl-2 and related proteins in controlling apoptosis. Although much …

Apoptosis is the main cause of primordial germ cell and oocyte degeneration in the
developing fetal ovary. In this study we examined by immunohistochemistry and …