Leptin plays a key role regulating food intake, body weight and fat mass. These critical
parameters are associated with an increased risk for digestive and mammary gland cancer …

Leptin serum levels are about 5 times higher in obese people than in normal individuals. We
aimed at investigating the signaling pathways induced by leptin in the human colonic cell …

Background & Aims: Obesity increases the risk of colon cancer, whereas physical activity
reduces the risk. Plasma levels of leptin increase in proportion to the level of obesity and are …

Background and aims Obesity increases the risk of colorectal cancer (CRC). Serum leptin
levels are markedly elevated in obese individuals, but the involvement of leptin in CRC …

Background and aims: Leptin, the product of the ob gene, has been suggested to increase
the risk of colon cancer. However, we have shown that although leptin stimulates epithelial …

Obesity is linked to increased risk of colon cancer, currently the third most common cancer.
Consequently rising levels of obesity worldwide are likely to significantly impact on obesity …

Background Obesity is associated with increased levels of leptin. The mitogenic actions of
leptin have been identified in various cell types. Because obesity may be a risk factor for …

Increased visceral adipose tissue results in elevated plasma leptin, which are associated
with increased risk of a number of obesity-related cancers. However, research is …

Adipose tissue secretes factors linked to colon cancer risk including leptin. A hallmark of
cancer is sustained angiogenesis. While leptin promotes angiogenesis in adipose tissue, it …

The incidence of colon cancer has increased in developed countries, possibly due to
sedentary lifestyle and high caloric diet. Experimental and epidemiological evidence …