Enhanced susceptibility to infection has long been recognized in children with congenital
deficiency of leptin or its receptor. Studies in mice have demonstrated that leptin deficiency …

We postulated that high fat diet enhances colon cell proliferation and carcinogenesis by
elevating serum leptin. To examine this possibility, the present study was conducted to …

Obesity is associated with an increased risk of breast cancer. Leptin, a hormone synthesised
essentially by adipose tissue, may be involved in cancer development. We examined the …

Purpose: Leptin, an adipocyte derived cytokine that is closely associated with obesity, was
recently shown to be involved in carcinogenesis and cancer progression. Because obesity is …

Epidemiological studies suggest that obesity increases the risk of developing several
cancers, including melanoma. Obesity increases the expression of angiogenic factors, such …

Misregulation of a pluripotency-associated transcription factor network in adult tissues is
associated with the expansion of rare, highly malignant tumor-initiating stem cells (TISCs) …

Background and aim: Leptin, a hormone mainly produced by fat cells, acts primarily on the
hypothalamus regulating energy expenditure and food intake. Leptin receptors are …

Obesity is a risk factor of breast cancers. As leptin, a hormone mainly secreted by white
adipocytes, elicits proliferative effects in some cell types, we tested the hypothesis that leptin …

BACKGROUND/AIMS: Leptin exerts potent immune modulatory properties. The aim of this
study was to determine leptin's anti-tumor effect in a murine model of hepatocellular …

It is well established that obesity increases the incidence and worsens the prognosis of
women's cancer. For breast cancer, women with obesity exhibit more than a twofold …