Background/Aims: The kidney plays a critical role in the control of blood pressure and its
elevation in salt-induced hypertension. Mitochondrial dysfunction, especially in energy …

Metabolic and functional abnormalities in the kidney precede or coincide with the initiation of
overt hypertension in the Dahl salt-sensitive (SS) rat. However, renal histological injury in SS …

Salt-sensitive (SS) hypertension is accompanied with an early onset of proteinuria, which
results from the loss of glomerular podocytes. Here, we hypothesized that glomerular …

Abstract Purpose of Review Essential or primary hypertension (HT) is a worldwide health
problem with no definitive cure. Although the exact pathogenesis of HT is not known, genetic …

Mitochondrial dysfunction is associated with cardiovascular damage; however, data on a
possible association with kidney damage are scarce. Here, we aimed at investigating …

Abstract High salt diet (HSD, 8% NaCl) contributes to salt-sensitive hypertension, this study
aimed to determine the effect of HSD on salt-sensitive hypertension by combining proteomic …

Renal proximal tubule cells from spontaneously hypertensive rats (SHR), compared with
normotensive Wistar–Kyoto rats (WKY), have increased oxidative stress. The contribution of …

We studied whether mitochondrial functions and Ca2+ metabolism were altered in Wistar
Kyoto normotensive (WKY) and spontaneous hypertensive rats (SHR). Ca2+ uptake was …

Background The kidney is always subjected to high metabolic demand. The aim of this study
was to characterize metabolic profiles of a rat model of chronic kidney disease (CKD) with …

It is well known that exercise training exhibits renal protective effects in animal models of
hypertension and chronic renal failure. However, the mechanisms regulating these effects of …