Caspase-3-mediated cleavage of Cdc6 induces nuclear localization of p49-truncated Cdc6 and apoptosis
H Yim, YH Jin, BD Park, HJ Choi… - Molecular biology of the …, 2003 - Am Soc Cell Biol
We show that Cdc6, an essential initiation factor for DNA replication, undergoes caspase-3–
mediated cleavage in the early stages of apoptosis in HeLa cells and SK-HEP-1 cells …
mediated cleavage in the early stages of apoptosis in HeLa cells and SK-HEP-1 cells …
Targeted destruction of DNA replication protein Cdc6 by cell death pathways in mammals and yeast
F Blanchard, ME Rusiniak, K Sharma… - Molecular biology of …, 2002 - Am Soc Cell Biol
The highly conserved Cdc6 protein is required for initiation of eukaryotic DNA replication
and, in yeast and Xenopus, for the coupling of DNA replication to mitosis. Herein, we show …
and, in yeast and Xenopus, for the coupling of DNA replication to mitosis. Herein, we show …
Cdc45 degradation during differentiation and apoptosis
S Pollok, F Grosse - Biochemical and biophysical research communications, 2007 - Elsevier
Cell division cycle protein 45 (Cdc45) is crucial for the initiation as well as the elongation
process of eukaryotic DNA replication. Our findings suggested that the Cdc45 protein is …
process of eukaryotic DNA replication. Our findings suggested that the Cdc45 protein is …
Pro-apoptotic role of Cdc25A: activation of cyclin B1/Cdc2 by the Cdc25A C-terminal domain
Cdc25A is a dual specificity protein phosphatase that activates cyclin/cyclin-dependent
protein kinase (Cdk) complexes by removing inhibitory phosphates from conserved …
protein kinase (Cdk) complexes by removing inhibitory phosphates from conserved …
Increased p34cdc2-dependent kinase activity during apoptosis: a possible activation mechanism of DNase I leading to DNA breakdown.
M Schroter, MC Peitsch, J Tschopp - European journal of cell …, 1996 - europepmc.org
Cells undergoing apoptosis typically exhibit distinctive morphological characteristics. Early
events include the rounding up of the cell, chromatin condensation, nuclear membrane …
events include the rounding up of the cell, chromatin condensation, nuclear membrane …
A caspase-dependent cleavage of CDC25A generates an active fragment activating cyclin-dependent kinase 2 during apoptosis
A Mazars, A Fernandez-Vidal, O Mondesert… - Cell Death & …, 2009 - nature.com
The cellular level of the CDC25A phosphatase is tightly regulated during both the normal
and genotoxic-perturbed cell cycle. Here, we describe a caspase-dependent cleavage of …
and genotoxic-perturbed cell cycle. Here, we describe a caspase-dependent cleavage of …
Cleavage of Cdc6 by caspase-3 promotes ATM/ATR kinase–mediated apoptosis of HeLa cells
H Yim, IS Hwang, JS Choi, KH Chun, YH Jin… - The Journal of cell …, 2006 - rupress.org
We show that caspase-3 cleaves Cdc6 at D290/S and D442/G sites, producing p32-tCdc6
(truncated Cdc6) and p49-tCdc6, respectively, during etoposide-or tumor necrosis factor …
(truncated Cdc6) and p49-tCdc6, respectively, during etoposide-or tumor necrosis factor …
Cell cycle dependent subcellular distribution of Cdc25B subtypes
ES Woo, RL Rice, JS Lazo - Oncogene, 1999 - nature.com
The dual specificity phosphatase and oncogene Cdc25B has been implicated in the G2/M
cell cycle checkpoint, but the mode by which it is regulated remains poorly understood …
cell cycle checkpoint, but the mode by which it is regulated remains poorly understood …
Cdc20 control of cell fate during prolonged mitotic arrest: do Cdc20 protein levels affect cell fate in response to antimitotic compounds?
J Nilsson - Bioessays, 2011 - Wiley Online Library
The fate of cells arrested in mitosis by antimitotic compounds is complex but is influenced by
competition between pathways promoting cell death and pathways promoting mitotic exit. As …
competition between pathways promoting cell death and pathways promoting mitotic exit. As …
Inactivation of Cdc2 increases the level of apoptosis induced by DNA damage
ABSTRACT A number of lines of evidence have suggested a possible involvement of the
mitosis-promoting protein kinase Cdc2 in the process of apoptotic cell death, and one recent …
mitosis-promoting protein kinase Cdc2 in the process of apoptotic cell death, and one recent …