Over past few years, there has been a dramatic increase in studying physiological
mechanisms of the activity of various signaling low-molecular molecules that directly or …

Carbon monoxide (CO), hydrogen sulfide (H 2 S), and nitric oxide (NO) constitute
endogenous gaseous molecules produced by specific enzymes. These gases are …

Recently, gaseous signaling molecules, such as carbon monoxide (CO), nitric oxide (NO),
and hydrogen sulfide (H2S), which were previously considered to be highly toxic, have been …

Ischaemic heart disease is one of the leading causes of morbidity and mortality worldwide.
The development of cardioprotective therapeutic agents remains a partly unmet need and a …

Introduction 3. Classical parameters of acclimatization to chronic hypoxia 4. Nitric oxide 4.1.
Role of NO in cardiac function 4.2. NO is an effector of cardioprotection 4.3. NOS isoforms …

Redox signalling in mitochondria plays an important role in myocardial
ischaemia/reperfusion (I/R) injury and in cardioprotection. Reactive oxygen and nitrogen …

Mitochondria play a fundamental role in the energetics of cardiac cells. Moreover,
mitochondria are involved in cardiac ischemia/reperfusion injury by opening the …

Significance: Sudden hypoxia requires a rapid response in tissues with high energy
demand. Mitochondria are rapid sensors for a lack of oxygen, but no consistent mechanism …

Myocardial ischemic injury is among the top 10 leading causes of death from cardiovascular
diseases worldwide. Myocardial ischemia is caused mainly by coronary artery occlusion or …

Despite recent progress, ischemic heart disease poses a persistent global challenge, driving
significant morbidity and mortality. The pursuit of therapeutic solutions has led to the …