Background—Superoxide (O2−) generated by enhanced xanthine oxidase (XO) activity may
contribute to the increased myocardial oxidative stress in heart failure (CHF). Because …

Allopurinol, an inhibitor of xanthine oxidase, increases myofilament calcium responsiveness
and blunts calcium cycling in isolated cardiac muscle. We sought to extend these …

Aims Oxidative stress, ie imbalance between reactive oxygen species (ROS) and antioxidant
defences, contributes to the progression of chronic heart failure (CHF). Acute inhibition of …

Xanthine oxidase (XO) is increased in human and rat left ventricular (LV) myocytes with
volume overload (VO) of mitral regurgitation and aortocaval fistula (ACF). In the setting of …

Oxidative stress is a hallmark of systemic illnesses, including heart failure. Nevertheless, the
overall importance of radical production in the heart remains conjectural; is it merely a …

We hypothesized that chronic xanthine oxidase inhibition (XOI) would have favorable effects
on both ventricular and vascular performance in evolving heart failure (HF), thereby …

The purine analog xanthine oxidase (XO) inhibitors (XOIs), allopurinol and oxypurinol, have
been reported to protect against heart failure secondary to myocardial infarction or rapid …

Objective: Xanthine oxidase (XO) inhibitors enhance myofilament Ca2+ responsiveness of
normal rat myocardium. We examined whether this inotropic action is preserved or …

Xanthine oxidase (XO) activity contributes to both abnormal excitation-contraction (EC)
coupling and cardiac remodeling in heart failure (HF). β-Adrenergic hyporesponsiveness …

BACKGROUND: Oxidative stress is implicated in cardiac remodeling and failure. We tested
whether xanthine oxidase (XO) inhibition could decrease myocardial oxidative stress and …