The recent discovery of glycine transporters in both the CNS and the periphery suggests that
the glycine transporter may play a critical role in NMDA receptor function by modulating …

In the central nervous system, glutamate is essential for a proper synaptic communication in
neuronal networks supporting critical behavioral activities such as learning and memory …

Current antipsychotic drugs are only partially effective in treating schizophrenia and there is
a clear need to develop better therapies. An alternative approach to develop new …

Multiple lines of evidence suggest that a dysfunction in the glutamatergic neurotransmission
via the N-methyl-D-aspartate (NMDA) receptors contributes to the pathophysiology of …

Publisher Summary This chapter discusses the recent developments made in glycine
transporter–1 inhibitor. The growing body of evidence implicating N-methyl-D-aspartate …

A growing body of evidence suggests that activation of the glutamatergic system, particularly
N-methyl-d-aspartate (NMDA) receptor function, may be a viable approach to the treatment …

The ionotropic glutamate receptor NMDA is allosterically modulated by glycine, a coagonist,
its presence is an absolute requirement for receptor activation. The transport of glycine in …

Glycine acts as an inhibitory neurotransmitter at glycine receptor (GlyR)-enriched synapses
and as an obligatory co-agonist at the N-methyl-D-aspartate (NMDA) receptor, where it …

While pharmacological blockade of dopamine D2 receptor can effectively suppress the
psychotic or positive symptoms of schizophrenia, there is no satisfactory medication for the …

Glycine plays a ubiquitous role in many biological processes. In the central nervous systemit
serves as an important neurotransmitter acting as an agonist at strychnine-sensitive glycine …