Brain inflammation and Alzheimer's-like pathology in individuals exposed to severe air pollution

L CALDERon-GARCIDUEnas, W Reed… - Toxicologic …, 2004 - journals.sagepub.com
Air pollution is a complex mixture of gases (eg, ozone), particulate matter, and organic
compounds present in outdoor and indoor air. Dogs exposed to severe air pollution exhibit …

Long-term air pollution exposure is associated with neuroinflammation, an altered innate immune response, disruption of the blood-brain barrier, ultrafine particulate …

L Calderón-Garcidueñas, AC Solt… - Toxicologic …, 2008 - journals.sagepub.com
Air pollution is a serious environmental problem. We investigated whether residency in cities
with high air pollution is associated with neuroinflammation/neurodegeneration in healthy …

Neuroinflammation, hyperphosphorylated tau, diffuse amyloid plaques, and down-regulation of the cellular prion protein in air pollution exposed children and young …

L Calderón-Garcidueñas, M Kavanaugh… - Journal of …, 2012 - content.iospress.com
Air pollution exposures have been linked to neuroinflammation and neuropathology.
Autopsy samples of the frontal cortex from control (n= 8) and pollution-exposed (n= 35) …

[HTML][HTML] The emerging risk of exposure to air pollution on cognitive decline and Alzheimer's disease–evidence from epidemiological and animal studies

J Kilian, M Kitazawa - Biomedical journal, 2018 - Elsevier
As incidence of Alzheimer's disease (AD) and other neurodegenerative diseases rise, there
is increasing interest in environmental factors which may contribute to disease onset and …

Pediatric respiratory and systemic effects of chronic air pollution exposure: nose, lung, heart, and brain pathology

L Calderón-Garcidueñas, M Franco-Lira… - Toxicologic …, 2007 - journals.sagepub.com
Exposures to particulate matter and gaseous air pollutants have been associated with
respiratory tract inflammation, disruption of the nasal respiratory and olfactory barriers …

A pilot study to assess effects of long-term inhalation of airborne particulate matter on early Alzheimer-like changes in the mouse brain

DP Bhatt, KL Puig, MW Gorr, LE Wold, CK Combs - PLoS One, 2015 - journals.plos.org
Exposure to air pollutants, including particulate matter, results in activation of the brain
inflammatory response and Alzheimer disease (AD)-like pathology in dogs and humans …

Urban air pollution: influences on olfactory function and pathology in exposed children and young adults

L Calderón-Garcidueñas, M Franco-Lira… - Experimental and …, 2010 - Elsevier
Mexico City (MC) residents are exposed to severe air pollution and exhibit olfactory bulb
inflammation. We compared the olfactory function of individuals living under conditions of …

Danger in the air: air pollution and cognitive dysfunction

G Cipriani, S Danti, C Carlesi… - American Journal of …, 2018 - journals.sagepub.com
Background: Clean air is considered to be a basic requirement for human health and well-
being. Objective: To examine the relationship between cognitive performance and ambient …

Effects of air pollution on the nervous system and its possible role in neurodevelopmental and neurodegenerative disorders

LG Costa, TB Cole, K Dao, YC Chang, J Coburn… - Pharmacology & …, 2020 - Elsevier
Recent extensive evidence indicates that air pollution, in addition to causing respiratory and
cardiovascular diseases, may also negatively affect the brain and contribute to central …

[HTML][HTML] Long-term exposure to ambient air pollution, APOE-ε4 status, and cognitive decline in a cohort of older adults in northern Manhattan

ER Kulick, MSV Elkind, AK Boehme, NR Joyce… - Environment …, 2020 - Elsevier
Background There is mounting evidence that long-term exposure to air pollution is related to
accelerated cognitive decline in aging populations. Factors that influence individual …