Human aging is accompanied by a progressive loss of muscle mass (sarcopenia). We tested
the hypothesis that older males (OMs, 70±4 yr, n= 9) would have a blunted myogenic …

Sarcopenia is a progressive age‐related loss of skeletal muscle mass and strength.
Parabiotic experiments show that circulating factors positively influence the proliferation and …

Background Myostatin (MSTN) is a key negative regulator of muscle mass in humans and
animals, having direct and indirect influences on molecular regulators of atrophy and …

Myostatin is an endogenous, negative regulator of muscle growth determining both muscle
fiber number and size. The myostatin pathway is conserved across diverse species ranging …

The molecular mechanisms behind aging‐related declines in muscle function are not well
understood, but the growth factor myostatin (MSTN) appears to play an important role in this …

Myostatin is a potent negative regulator of skeletal muscle mass, but its role in human
skeletal muscle hypertrophy and atrophy is sparsely described. Muscle biopsies were …

BACKGROUND: Myostatin is a recently discovered member of the TGF-b superfamily of
genes. It is expressed in skeletal muscle and believed to suppress muscle growth. Myostatin …

Background Myostatin is a protein synthesized and secreted by skeletal muscle that
negatively regulates muscle mass. The extent to which circulating myostatin levels change …

OBJECTIVE—Obesity is associated with endocrine abnormalities that predict the
progression of insulin resistance to type 2 diabetes. Because skeletal muscle has been …

Purpose There is mounting evidence that skeletal muscle produces and secretes
biologically active proteins or “myokines” that facilitate metabolic cross talk between organ …