Myostatin is an endogenous inhibitor of muscle conserved across diverse species. In the
absence of myostatin, there is massive muscle growth in mice, cattle, and humans. Previous …

Aim Some health benefits of exercise may be explained by an altered secretion of myokines.
Because previous focus has been on upregulated myokines, we screened for …

Sarcopenia is the progressive loss of skeletal muscle mass and function with advancing
age, leading to reduced mobility and quality of life. We tested the hypothesis that antibody …

Myostatin is a member of the transforming growth factor (TGF)-β superfamily. It is expressed
by animal and human skeletal muscle cells where it limits muscle growth and promotes …

Myostatin is a powerful negative regulator of skeletal muscle mass in mammalian species. It
plays a key role in skeletal muscle homeostasis and has now been well described since its …

Since its discovery in 1997, myostatin has quickly been established as a key regulator of
skeletal muscle mass. Recent developments strengthen the idea that myostatin will be an …

There is much interest in developing anti-myostatin agents to reverse or prevent muscle
atrophy in adults, so it is important to characterize the effects of reducing myostatin activity …

Previous findings have provided strong evidence that myostatin functions as a negative
regulator of muscle mass during development and growth. In the present study, we test the …

Muscle regeneration through myostatin inhibition : Current Opinion in Rheumatology Muscle
regeneration through myostatin inhibition : Current Opinion in Rheumatology Log in or Register …

Mutations in the myostatin gene are associated with hypermuscularity, suggesting that
myostatin inhibits skeletal muscle growth. We postulated that increased tissue-specific …