Skeletal muscle fibrosis is a major pathological hallmark of chronic myopathies in which
myofibers are replaced by progressive deposition of collagen and other extracellular matrix …

Constitutive myostatin gene knockout in mice causes excessive muscle growth during
development. To examine the effect of knocking out the myostatin gene after muscle has …

Myostatin is a newly described member of the TGF-β superfamily acting as a secreted
negative regulator of skeletal muscle mass in several species, but whose mode of action …

Skeletal muscle fiber generation occurs principally in two myogenic phases:(1) Primary
(embryonic) myogenesis when myoblasts proliferate and fuse to form primary myotubes and …

Myostatin, a member of the transforming growth factor beta (TGF-β) superfamily, was first
described in 1997. Since then, myostatin has gained growing attention because of the …

The presence of sufficient skeletal muscle is of paramount importance for body function.
Cachexia can be defined as a wasting syndrome describing the progressive loss of both …

Myostatin, a TGF-β family member, is a negative regulator of muscle growth. Here, we
generated transgenic mice that expressed myostatin mutated at its cleavage site under the …

Muscle mass loss accompanies periods of bedrest and limb immobilization in humans and
requires rehabilitation exercise to effectively restore mass and function. Although recent …

Myostatin is a negative regulator of skeletal muscle size, previously shown to inhibit muscle
cell differentiation. Myostatin requires both Smad2 and Smad3 downstream of the activin …

Myostatin (MSTN), a member of the transforming growth factor-β superfamily, can negatively
regulate the growth and development of skeletal muscle by autocrine or paracrine signaling …