Myostatin (Mstn) is a secreted growth factor belonging to the tranforming growth factor (TGF)-
β superfamily. Inactivation of murine Mstn by gene targeting, or natural mutation of bovine or …

A human therapeutic that specifically modulates skeletal muscle growth would potentially
provide a benefit for a variety of conditions including sarcopenia, cachexia, and muscular …

Inactivating mutations of the mammalian myostatin gene are associated with increased
muscle mass and decreased fat mass; conversely, myostatin transgenic mice that …

Myostatin plays a major role in muscle growth and development and animals with disruption
of this gene display marked increases in muscle mass. Little is known about muscle …

Myostatin (Mstn) is a secreted growth factor expressed in skeletal muscle and adipose tissue
that negatively regulates skeletal muscle mass. Mstn−/− mice have a dramatic increase in …

Abstract Myostatin-deficient mice (MSTN−/−) display excessive muscle mass and this is
associated with a profound loss of oxidative metabolic properties. In this study we analysed …

Genetic deletion of Myostatin, a member of the Transforming Growth Factor-beta family of
signalling molecules, resulted in excessive growth of skeletal muscle. It demonstrated the …

Background: In chronic heart failure (CHF), cardiac cachexia is often associated with the
terminal stage of this disease. In animal studies it has been demonstrated that myostatin, a …

Myostatin is a member of the transforming growth factor-beta/bone morphogenetic protein
(TGF-β/BMP) super-family of secreted factors that functions as a potent inhibitor of skeletal …

Transgenic mice lacking a functional myostatin (MSTN) gene demonstrate greater skeletal
muscle mass resulting from muscle fiber hypertrophy and hyperplasia (McPherron, AC, AM …