Simvastatin affects Nrf2/MAPK signaling pathway and hepatic histological structure change in Gambusia affinis
S Bao, J Lin, M Xie, C Wang, X Nie - Chemosphere, 2021 - Elsevier
Simvastatin (SV) is a typical lipid-lowering agent detected widely in waters, so its latent toxic
effects to fish are deserved of concern. The purposes of this study aim at revealing the …
effects to fish are deserved of concern. The purposes of this study aim at revealing the …
Atorvastatin causes oxidative stress and alteration of lipid metabolism in estuarine goby Mugilogobius abei
Y Wang, C Wang, M Xie, T Tang, Z Wang, X Nie - Environmental Pollution, 2021 - Elsevier
The potential effects of the environmental residues of Atorvastatin (ATV) as a widely used
antilipemic agent on aquatic organisms deserve more investigations because of its high …
antilipemic agent on aquatic organisms deserve more investigations because of its high …
Response of PXR signaling pathway to simvastatin exposure in mosquitofish (Gambusia affinis) and its histological changes
S Bao, X Nie, Y Liu, C Wang, S Liu - Ecotoxicology and environmental …, 2018 - Elsevier
As a widely used lipid lowering agent, simvastatin recently has been frequently detected in
aquatic environment and the potential adverse effects from simvastatin exposure to non …
aquatic environment and the potential adverse effects from simvastatin exposure to non …
Effects of simvastatin on the PXR signaling pathway and the liver histology in Mugilogobius abei
C Wang, P Ku, X Nie, S Bao, Z Wang, K Li - Science of The Total …, 2019 - Elsevier
Simvastatin is one of the most commonly cholesterol-lowering prescribed drugs all over the
world. With the increase of consumption of these pharmaceuticals and subsequent their …
world. With the increase of consumption of these pharmaceuticals and subsequent their …
Simvastatin as an emerging pollutant on non-target aquatic invertebrates: effects on antioxidant-related genes in Daphnia magna
S Liu, J Lin, R Ding, X Nie - Environmental Science and Pollution …, 2022 - Springer
Simvastatin (SIM) is one of the most widely used lipid-lowering drugs and consequently has
been frequently detected in various waters. However, its potential adverse effects and toxic …
been frequently detected in various waters. However, its potential adverse effects and toxic …
Simvastatin affects the PPARα signaling pathway and causes oxidative stress and embryonic development interference in Mugilogobius abei
C Wang, T Tang, Y Wang, X Nie, K Li - Aquatic Toxicology, 2021 - Elsevier
Simvastatin (SV) is a common hypolipidemic drug in clinical medicine that can reduce
endogenous cholesterol biosynthesis by inhibiting hydroxyl-methyl-glutaryl coenzyme A …
endogenous cholesterol biosynthesis by inhibiting hydroxyl-methyl-glutaryl coenzyme A …
Effects of atorvastatin on the Sirtuin/PXR signaling pathway in Mugilogobius chulae
Y Zhao, M Xie, C Wang, Y Wang, Y Peng… - … Science and Pollution …, 2023 - Springer
Atorvastatin (ATV) is a hypolipidemic drug widely detected in the aquatic environment.
Nevertheless, limited information is provided about the toxic effects of ATV on estuary or …
Nevertheless, limited information is provided about the toxic effects of ATV on estuary or …
Hypoxia aggravates the burden of yellowstripe goby (Mugilogobius chulae) under atorvastatin exposure
Y Wang, T Tang, J Ren, Y Zhao, Y Hou, X Nie - Aquatic Toxicology, 2023 - Elsevier
In the present study, an estuarine benthic fish, Mugilogobius chulae (M. chulae), was
exposed to hypoxia, atorvastatin (ATV), a highly used and widely detected lipid-lowering …
exposed to hypoxia, atorvastatin (ATV), a highly used and widely detected lipid-lowering …
Comparison of toxic effects of atorvastatin and gemfibrozil on Daphnia magna
L Hu, R Ding, X Nie - Comparative Biochemistry and Physiology Part C …, 2022 - Elsevier
Atorvastatin (ATV) and gemfibrozil (GEM) are two typical lipid-lowering pharmaceuticals with
different action modes, which are frequently detected in various water bodies owning to their …
different action modes, which are frequently detected in various water bodies owning to their …
The Nrf2 molecule trigger antioxidant defense against acute benzo (a) pyrene exposure in the thick shell mussel Mytilus coruscus
P Qi, Z Tang - Aquatic Toxicology, 2020 - Elsevier
The NF-E2-related factor 2 (Nrf2), an ubiquitous, evolutionarily conserved transcription
factor, acts as a major sensor of oxidative stress in cells. In the present study, a Nrf2 …
factor, acts as a major sensor of oxidative stress in cells. In the present study, a Nrf2 …