Amylinergic control of food intake

TA Lutz - Physiology & behavior, 2006 - Elsevier
Amylin is a pancreatic B-cell hormone that plays an important role in the regulation of
nutrient fluxes. As such, amylin reduces food intake in laboratory animals and man, slows …

Effects of amylin-related peptides on food intake, meal patterns, and gastric emptying in rats

RD Reidelberger, L Kelsey… - American Journal of …, 2002 - journals.physiology.org
We previously demonstrated that amylin inhibits food intake and gastric emptying in rats with
half-maximal effective doses (ED50s) of 8 and 3 pmol· kg− 1· min− 1 and maximal inhibitions …

Amylin: pharmacology, physiology, and clinical potential

DL Hay, S Chen, TA Lutz, DG Parkes, JD Roth - Pharmacological reviews, 2015 - ASPET
Amylin is a pancreatic β-cell hormone that produces effects in several different organ
systems. Here, we review the literature in rodents and in humans on amylin research since …

Salmon calcitonin distributes into the arcuate nucleus to a subset of NPY neurons in mice

HL Zakariassen, LM John, J Lykkesfeldt, K Raun… - …, 2020 - Elsevier
The amylin receptor (AMY) and calcitonin receptor (CTR) agonists induce acute suppression
of food intake in rodents by binding to receptors in the area postrema (AP) and potentially by …

Central and peripheral administration of amylin induces energy expenditure in anesthetized rats

T Osaka, A Tsukamoto, Y Koyama, S Inoue - Peptides, 2008 - Elsevier
Amylin is a peptide hormone that is co-released with insulin from pancreatic β-cells following
a meal. Intracerebroventricular (icv) administration of amylin (1–100pmol), or an amylin …

Amylin acts in the central nervous system to increase sympathetic nerve activity

C Fernandes-Santos, Z Zhang, DA Morgan… - …, 2013 - academic.oup.com
The pancreatic hormone amylin acts in the central nervous system (CNS) to decrease food
intake and body weight. We hypothesized that amylin action in the CNS promotes energy …

Amylinergic control of food intake in lean and obese rodents

CN Boyle, TA Lutz - Physiology & behavior, 2011 - Elsevier
Obesity develops despite a complex and seemingly well orchestrated network that controls
eating, energy expenditure and ultimately body weight; many of the involved signals are …

Functional study of amylin and regulation of amylin receptor

X Huang - 2010 - scholarshare.temple.edu
Amylin, a 37 amino acid peptide secreted from pancreatic beta cells upon stimulation by
meal/glucose, belongs to the family of the calcitonin or calcitonin gene-related peptide …

A selective role for receptor activity‐modifying proteins in subchronic action of the amylin selective receptor agonist NN1213 compared with salmon calcitonin on body …

S Arrigoni, C Le Foll, A Cabak, S Lundh… - European Journal of …, 2021 - Wiley Online Library
The role of receptor activity‐modifying proteins (RAMPs) in modulating the pharmacological
effects of an amylin receptor selective agonist (NN1213) or the dual amylin–calcitonin …

The ability of amylin to reduce eating depends on the protein content of the diet

T Riediger, S Michel, K Forster, TA Lutz - Appetite, 2009 - zora.uzh.ch
Numerous lines of evidence indicate that the pancreatic hormone amylin contributes to meal-
ending satiation. This action seems to be mediated by direct action of amylin on area …