In this study, we characterized the role of host cell protein tyrosyl-DNA phosphodiesterase 2
(TDP2) activity, also known as VPg unlinkase, in picornavirus infections in a human cell …

Viruses of the Enterovirus genus of picornaviruses, including poliovirus, coxsackievirus B3
(CVB3), and human rhinovirus, commandeer the functions of host cell proteins to aid in the …

A previously described mammalian cell activity, called VPg unlinkase, specifically cleaves a
unique protein–RNA covalent linkage generated during the viral genomic RNA replication …

Using poliovirus, the prototypic member of Picornaviridae, we have further characterized a
host cell enzymatic activity found in uninfected cells, termed “unlinkase,” that recognizes and …

Cardioviruses cause diseases in many animals including, in rare cases, humans. Although
they share common features with all picornaviruses, cardioviruses have unique properties …

VPg uridylylation is essential for picornavirus RNA replication. The VPg uridylylation
reaction consists of the binding of VPg to 3D polymerase (3Dpol) and the transfer of UMP by …

Previously, it was shown that pyrrolidine dithiocarbamate (PDTC) inhibits proteolytic
polyprotein processing and replication of human rhinovirus by transporting metal ions into …

We have shown previously that poliovirus infection disrupts cytoplasmic P-bodies in infected
mammalian cells. During the infectious cycle, poliovirus causes the directed cleavage of …

Picornavirus RNA replication is initiated by VPg uridylylation, during which the hydroxyl
group of the third tyrosine residue of the virally encoded protein VPg is covalently linked to …

RNA granules are cellular structures, which play an important role in mRNA translation,
storage, and degradation. Animal (+) RNA viruses often co-opt RNA granule proteins for …