A comprehensive meeting on biological responses to DNA damage organized by Alan
Lehmann, Deborah Barnes, Wouter Ferro, Robert Fuchs, Jan Hoeijmakers, Roland Kanaar …

DNA Repair Mechanisms is an account of the proceedings at a major international
conference on DNA Repair Mechanisms held at Keystone, Colorado on February 1978. The …

The history of the repair of damaged DNA can be traced to the mid-1930s. Since then
multiple DNA repair mechanisms, as well as other biological responses to DNA damage …

DNA damage appears to be a fundamental problem for life. In this chapter we review evi‐-
dence indicating that DNA damages are a major primary cause of cancer. DNA damages …

DNA repair has finally achieved a level of recognition commensurate with its fundamental
importance in genomic maintenance. It has become apparent that DNA repair is not merely …

It has been estimated that there is a 90% overlap between mutagenicity and carcinogenicity
of environmental chemicals (1) and that environmental exposure to carcinogens contributes …

The human genome, comprising three billion base pairs coding for 30000–40000 genes, is
constantly attacked by endogenous reactive metabolites, therapeutic drugs and a plethora of …

There is increasing interest in gene-specific repair studies. This aspect of DNA repair is
currently under intense investigation and new laboratories are entering the field. The data …

DNA repair is an important molecular defense system against agents that cause cancer,
degenerative diseases, and aging. Several repair systems in humans protect the genome by …

Cellular genomes are vulnerable to an array of DNA-damaging agents, of both endogenous
and environmental origin. Such damage occurs at a frequency too high to be compatible …