Reactive oxygen species (ROS) and reactive nitrogen species (RNS) are generated
throughout the human body. Enzymatic and nonenzymatic antioxidants detoxify ROS and …

Reactive oxygen species and reactive nitrogen species are mediators of lung tissue
damage. To minimize the effect of oxidative stress, the lung is well equipped with an …

Induction of oxidant stress either by raising ambient oxygen concentrations, adding toxins
that augment intracellular oxidant formation, generating ischemia followed by tissue …

Reactive oxygen species (ROS) are products of normal cellular metabolism and are known
to act as second messengers. Under physiological conditions, ROS participate in …

Reactive oxygen species (ROS), either derived from exogenous sources or overproduced
endogenously, can disrupt the body's antioxidant defenses leading to compromised redox …

As eukaryotic life evolved, so too did the need for a source of energy that meets the
requirements of complex organisms. Oxygen provides this vast potential energy source, but …

The lung is a delicate organ with a large surface area that is continuously exposed to the
external environment, and is therefore highly vulnerable to exogenous sources of oxidative …

Pulmonary oxidant stress plays an important pathogenetic role in disease conditions
including acute lung injury/adult respiratory distress syndrome (ALI/ARDS), hyperoxia …

Studies have implicated active oxygen species (AOS) in the pathogenesis of various lung
diseases. Many chemical and physical agents in the environment are potent generators of …

Reactive oxygen and nitrogen species can be generated endogenously (by mitochondria,
peroxisomes, and phagocytic cells) and exogenously (by pollutions, UV exposure …