Hydrolytic zinc enzymes are common targets for protein design. The versatility of the zinc
chemistry can be combined with the usage of small protein scaffolds for biocatalytic …

The isomerization of l-amino acids in peptides and proteins into d-configuration under
physiological conditions would affect the physiological dysfunction and caused protein …

The total chemical synthesis of proteins has great potential for increasing our understanding
of the molecular basis of protein function. The introduction of native chemical ligation …

Metal ions and complexes that hydrolyze peptides and proteins have become increasingly
important in recent years. These reagents have shown great promise for use in a variety of …

Genetically encoded unnatural amino acids could facilitate the design of proteins and
enzymes of novel function, but correctly specifying sites of incorporation and the identities …

The mechanism of the recently described N→ C direction peptide synthesis through silver‐
promoted coupling of N‐protected amino acids with thioacetylated amino esters was …

The mandatory use of Nα-protecting group for amino acids, which invokes protection and
deprotection operations and imposes a significant negative effect on environment …

The new specific hydrolysis of histidine-containing peptides promoted by cis-[Pt (en)(H2O) 2]
2+ was investigated by electrospray ionization mass spectrometry (ESI-MS) and nuclear …

Protein design is a useful strategy to interrogate the protein structure‐function relationship.
We demonstrate using a highly modular 3‐stranded coiled coil (TRI‐peptide system) that a …

This tutorial review outlines the modern ligation methods that enable the efficient total
chemical synthesis of enzymes and other protein molecules. Key to this success is the …