Calcium (Ca2+) is a versatile secondary messenger involved in the regulation of a plethora
of different signaling pathways for cell maintenance. Specifically, intracellular Ca2+ …

Mitochondria absorb calcium (Ca2+) at the expense of the electrochemical gradient
generated during respiration. The influx of Ca2+ into the mitochondrial matrix helps maintain …

Calcium signaling is essential for neuronal function, and its dysregulation has been
implicated across neurodegenerative diseases, including Alzheimer's disease (AD). A close …

Mitochondria represent the main powerhouse of the cell, producing the majority of ATP
molecules needed for all the cell processes. In particular, excitable cells, such as neurons …

Abstract Mitochondrial calcium (Ca2+) dynamics play critical roles in regulating vital
physiological conditions in the brain. Importantly, Mitochondria‐associated endoplasmic …

Mitochondria are pivotal organelles in calcium (Ca2+) handling and signalling, constituting
intracellular checkpoints for numerous processes that are vital for cell life. Alterations in …

Calcium is used in many cellular processes and is maintained within the cell as free calcium
at low concentrations (approximately 100 nM), compared with extracellular (millimolar) …

Mitochondria are essential for ensuring numerous fundamental physiological processes
such as cellular energy, redox balance, modulation of Ca2+ signaling and important …

Mitochondria are crucial in different intracellular pathways of signal transduction.
Mitochondria are capable of decoding a variety of extracellular stimuli into markedly different …

Alzheimer's disease (AD) is a hereditary and sporadic neurodegenerative illness defined by
the gradual and cumulative loss of neurons in specific brain areas. The processes that …