Nitric oxide (NO) is an important molecular messenger accounting for endothelium-derived
relaxing factor. Recently, NO synthase (NOS) from cultured endothelial cells has been …

Protein kinase C (PKC) plays a key role in a variety of signal transduction processes. The
promoter region of the endothelial constitutive nitric oxide synthase (ecNOS) gene contains …

Nitric oxide (NO) is synthesized froml-arginine by the Ca2+/calmodulin-sensitive endothelial
NO synthase (NOS) isoform (eNOS). The present study assesses the role of …

Endothelial nitric oxide synthase (eNOS) is a key enzyme in nitric oxide–mediated signal
transduction in mammalian cells. Its catalytic activity is regulated both by regulatory proteins …

The intracellular regulation of nitric oxide synthase has been the focus of intense
investigation. Bioassay studies using vascular rings have suggested that protein kinase C …

Endothelial nitric-oxide synthase (eNOS) is phosphorylated at Ser-1179 (bovine sequence)
by Akt after growth factor or shear stress stimulation of endothelial cells, resulting in …

Recent studies have indicated that endothelial nitric-oxide synthase (eNOS) is regulated by
reversible phosphorylation in intact endothelial cells. AMP-activated protein kinase (AMPK) …

Vascular endothelium responds to Ca (2+)-mobilizing agonists by producing nitric oxide
(NO), a potent vasodilator and inhibitor of platelet aggregation. Regulation of constitutively …

In 1980, Furchgott and Zawadzki demonstrated that the relaxation of vascular smooth
muscle cells in response to acetylcholine is dependent on the anatomical integrity of the …

Bradykinin (BK) acutely increases endothelial nitric oxide (NO) production by activating
endothelial NO synthase (eNOS), and this increase is in part correlated with enhanced …