Endothelium-derived nitric oxide (NO) is an important regulator of vascular function. NO is
produced by endothelial NO synthase (eNOS) whose function is modulated, in part, by …

Background We analyzed the activity of nitric oxide synthase in the rat heart to study whether
this activity is affected by high blood pressure. Hearts from young (3 to 4 weeks old) and …

To determine whether angiotensin (ANG) II, a vasoconstrictor hormone, activates constitutive
nitric oxide synthase (cNOS) in endothelial cells (ECs), we investigated the cellular …

The transient increase in [Ca2+] i in endothelial cells after stimulation with bradykinin can
account for the initiation but not the sustained production of nitric oxide (NO). Therefore, we …

Hydrogen peroxide mediates vasodilation, but the mechanisms responsible for this process
remain undefined. We examined the effect of H2O2 on nitric oxide (NO⋅) production and the …

Vascular endothelial cells synthesize nitric oxide (NO) in response to agonists that elevate
cytosolic free Ca2+ concentrations. Once activated, NO synthase (NOS) requires arginine …

The vascular endothelium synthesises the vasodilator and anti-aggregatory mediator nitric
oxide (NO) from L-arginine. This action is catalysed by the action of NO synthases, of which …

Since its discovery, endothelium-derived nitric oxide (NO) has become one of the most
intensely investigated molecules in the field of cardiovascular physiology. Although initial …

Nitric oxide (NO), which accounts for the biological properties of endothelium-derived
relaxing factor, is generated by NO synthase (NOS). The vascular endothelium contains two …

Endothelial nitric oxide synthase (NOS) is a constitutively expressed flavin-containing heme
protein that catalyzes the formation of NO froml-arginine, NADPH, and molecular oxygen …