Nitric oxide (NO) and cyclooxygenase (COX) derived prostaglandins (PGs) are involved in
vascular homeostasis. Contradictory results have been obtained in previous studies on the …

The production of endothelium-derived relaxing factor (EDRF), known to be nitric oxide
(NO), is triggered by a rise in the cytoplasmic calcium concentration ([Ca2+] i) subsequent to …

Nitric oxide (NO) produced in the endothelium via the enzyme endothelial nitric-oxide
synthase (eNOS) is an important vasoactive compound. Wild-type (WT) eNOS is localized to …

1. Recent studies have provided insight into how the expression of endothelial cell nitric
oxide synthase (ecNOS) is regulated. 2. The promoter of ecNOS has several features that …

To elucidate whether cytokines induce nitric oxide synthase in vascular smooth muscle cells,
we studied the effects of human recombinant interleukin-1 beta on the synthesis and release …

The free radical nitric oxide (NO) has emerged as an important signal effector molecule that
controls critical functions in the mammalian cardiovascular system in both healthy and …

Nitric oxide (NO) was discovered to be a potent vasodilator, inhibitor of platelet aggregation,
and active species of nitroglycerin before the discovery of endothelium-derived relaxing …

▪ Abstract Nitric oxide (NO) is a small, diffusible, lipophilic free radical gas that mediates
significant and diverse signaling functions in nearly every organ system in the body. The …

Previous studies have suggested that NO may play an important role in protecting the renal
vessels from angiotensin II (ANGII)-mediated vasoconstriction. One possible mechanism for …

Largely assumed to be a Ca2+-/calmodulin-dependent enzyme, the endothelial constitutive
nitric oxide (NO) synthase (NOS III) can be activated by agonists as a consequence of an …