Neuropathic pain takes a heavy toll on individual well-being, while current therapy is far from
desirable. Herein, we assessed the analgesic effect of β-elemene, a chief component in the …

Despite accumulating evidence of the clinical effectiveness of acupuncture, its mechanism
remains largely unclear. We assume that molecular signaling around the acupuncture …

Fibromyalgia (FM) is a painful chronic condition that significantly impacts the quality of life,
posing challenges for clinical management. Given the difficulty of understanding the …

Bone cancer pain (BCP) is a common source of pain in patients with advanced stage and
metastatic cancer; however, existing treatment for this kind of pain remains deficient. Being …

In the present study, the ability of baicalin to relieve neuropathic pain due to spinal nerve
ligation in rats was explored, and the relationship between baicalin and α2‑adrenoceptors …

Spinal neuroinflammation plays a critical role in the genesis of neuropathic pain.
Accumulating data suggest that abscisic acid (ABA), a phytohormone, regulates …

Several lines of evidence indicate that phosphatidylinositol 3-kinase (PI3K) and PI3K-protein
kinase B/Akt (PKB/Akt) signal pathway mediate the pain hypersensitivity induced by …

The interaction between electroacupuncture and an N-methyl-d-aspartic acid (NMDA)
receptor antagonist,(DL-2-amino-5-phosphonopentanoic acid; AP5), or an (±)-α-Amino-3 …

Abscisic acid (ABA) is a phytohormone with modulatory roles. The anti-inflammatory effect of
this hormone has been reported on different animal tissues. Immediately after spinal cord …

Background Several studies have shown that scorpion venom peptide BmK AGAP has an
analgesic activity. Our previous study also demonstrated that intraplantar injection of BmK …