Ethnopharmacological relevance The infusion or decoction of Mirabilis jalapa leaves is used
in traditional medicine in Brazil to treat inflammatory and painful diseases. Thus, the present …

Background It has been shown that spinal PKA/CREB signaling pathway is involved in
neuropathic and inflammatory pain, but its effects on bone cancer pain have not previously …

Treatment of neuropathic pain remains a challenge for modern medicine due to the
insufficiently understood molecular mechanisms of its development and maintenance. One …

BACKGROUND: Electroacupuncture (EA), as a traditional clinical method, is widely
accepted in pain clinics, but the analgesic effect of EA has not been fully demonstrated. In …

Purpose: To investigate the antinociceptive effect of the total alkaloids (TA) isolated from the
seeds of Areca catechu L.(SAC) and to elucidate the probable mechanism of action …

This study investigated the ERK pathway of the peripheral nervous system and discovered a
gender-specific pattern of ERK activation in the dorsal root ganglion of an acid-induced …

The present study was designed to investigate the ameliorative role of ethanolic extract from
leaves of Butea monosperma in chronic constriction injury (CCI) of sciatic nerve induced …

Acupuncture or electroacupuncture (EA) has been demonstrated to have a powerful
antihypernociceptive effect on inflammatory pain. The attenuation of G protein‐coupled …

This study aimed to evaluate the effect of a single administration of IB-MECA, an A3
adenosine receptor agonist, upon the nociceptive response and central biomarkers of rats …

Kielmeyera rugosa is a medicinal plant known in Northeastern Brazil as 'pau‐santo', and it is
used in the treatment of several tropical diseases such as malaria, schistosomiasis, and …