Background and aims This study evaluated the effects of resveratrol on arterial aging and
the renin–angiotensin system (RAS) in mice and vascular smooth muscle cells (VSMCs) …

Aim: Silencing information regulator (SirT1), a NAD-dependent histone deacetylase, is an
essential mediator of longevity in normal cells by calorie restriction. SirT1 has many …

The renin-angiotensin system (RAS), especially the angiotensin II (Ang II)/angiotensin II type
1 receptor (AT1R) axis, plays an important role in the aging process of the kidney, through …

OBJECTIVE: Senescence of vascular cells contributes to the development of cardiovascular
diseases and the overall aging. This study was undertaken to investigate the effects of …

BACKGROUND AND AIMS: 2, 3, 5, 4′-tetrahydroxystilbene-2-O-β-d-glucoside (THSG), a
resveratrol analog with glucoside, has been shown in various studies to inhibit proliferation …

Purpose Resveratrol (RESV; trans-3, 5, 4′-trihydroxystilbene) has emerged as a potential
new therapeutic for age-related atherosclerotic diseases. However, the effect of RESV on …

Advanced glycation end-products (AGEs) of plasma proteins and/or matrix proteins are
candidate mediators for various vascular complications such as atherosclerosis. We …

Objective—Endothelial vasodilator functions are progressively impaired with aging, which
may account in part for the increased incidence of cardiovascular events in elderly people …

Background. This study evaluated whether the change in the renin‐angiotensin system
(RAS) is associated with arterial aging in mice. Methods. Histologic changes and …

Vascular aging is characterized by vascular cell senescence, increased oxidative stress,
and endothelial and inducible nitric oxide (NO) synthase (eNOS/iNOS) imbalance, which …