Microglial activation and inflammation caused by traffic-related particulate matter

KJ Bai, KJ Chuang, CL Chen, MK Jhan… - Chemico-biological …, 2019 - Elsevier
Neurotoxicity caused by particulate matter (PM) has been highlighted as being a potential
risk factor for neurodegenerative diseases. However, the effects of brain inflammation in …

PM2. 5 exposure aggravates oligomeric amyloid beta-induced neuronal injury and promotes NLRP3 inflammasome activation in an in vitro model of Alzheimer's …

BR Wang, JQ Shi, NN Ge, Z Ou, YY Tian… - Journal of …, 2018 - Springer
Background Numerous studies suggested that PM2. 5 exposure was associated with
increased risk of Alzheimer's disease (AD). But the precise mechanisms by which PM2. 5 …

Particulate matter induced enhancement of inflammatory markers in the brains of apolipoprotein E knockout mice

A Campbell, JA Araujo, H Li, C Sioutas… - … of nanoscience and …, 2009 - ingentaconnect.com
Exposure to air particulate matter (PM) present in urban environments have been shown to
induce systemic prooxidant and proinflammatory effects in apolipoprotein E knockout (ApoE …

Particulate matter in polluted air may increase biomarkers of inflammation in mouse brain

A Campbell, M Oldham, A Becaria, SC Bondy… - Neurotoxicology, 2005 - Elsevier
The etiology of neurodegenerative disorders is at present unknown. However, many of these
disorders are associated with an increase in oxidative and inflammatory events. Although a …

The air we breathe: air pollution as a prevalent proinflammatory stimulus contributing to neurodegeneration

M Jankowska-Kieltyka, A Roman… - Frontiers in Cellular …, 2021 - frontiersin.org
Air pollution is regarded as an important risk factor for many diseases that affect a large
proportion of the human population. To date, accumulating reports have noted that …

Possible association between PM2. 5 and neurodegenerative diseases: A systematic review

A Cristaldi, M Fiore, GO Conti, E Pulvirenti… - Environmental …, 2022 - Elsevier
Air pollution is one of the most serious environmental problems that afflict our planet and
one of the greatest risk factors for human health. In particular, PM 2.5 is able to cross the …

Recent advances in understanding the mechanisms of PM2. 5-mediated neurodegenerative diseases

X Zhu, X Ji, Y Shou, Y Huang, Y Hu, H Wang - Toxicology Letters, 2020 - Elsevier
PM 2.5 particles are widely believed to be associated with respiratory and cardiovascular
diseases. However, recent studies have reported that PM 2.5 may be associated with …

Urban airborne PM2. 5-activated microglia mediate neurotoxicity through glutaminase-containing extracellular vesicles in olfactory bulb

X Chen, J Guo, Y Huang, S Liu, Y Huang, Z Zhang… - Environmental …, 2020 - Elsevier
Emerging evidence has showed that exposure to airborne particulate matter (PM) with an
aerodynamic diameter less than 2.5 μm (PM 2.5) is associated with neurodegeneration. Our …

PM2. 5, SO2 and NO2 co-exposure impairs neurobehavior and induces mitochondrial injuries in the mouse brain

T Ku, X Ji, Y Zhang, G Li, N Sang - Chemosphere, 2016 - Elsevier
Air pollution is a serious environmental health problem that has been previously associated
with neuropathological disorders. However, current experimental evidence mainly focuses …

Fine particulate matter induces mitochondrial dysfunction and oxidative stress in human SH-SY5Y cells

Y Wang, M Zhang, Z Li, J Yue, M Xu, Y Zhang… - Chemosphere, 2019 - Elsevier
Exposure to ambient fine particulate matter (PM 2.5) is associated with neurodegenerative
diseases. Mitochondrion is key to brain degeneration. However, the underlying mechanism …