[HTML][HTML] Features of microglia and neuroinflammation relevant to environmental exposure and neurotoxicity

AD Kraft, GJ Harry - International journal of environmental research and …, 2011 - mdpi.com
Microglia are resident cells of the brain involved in regulatory processes critical for
development, maintenance of the neural environment, injury and repair. They belong to the …

A 3D human triculture system modeling neurodegeneration and neuroinflammation in Alzheimer's disease

J Park, I Wetzel, I Marriott, D Dréau, C D'Avanzo… - Nature …, 2018 - nature.com
Alzheimer's disease (AD) is characterized by beta-amyloid accumulation, phosphorylated
tau formation, hyperactivation of glial cells, and neuronal loss. The mechanisms of AD …

[HTML][HTML] Role of PKA/CREB/BDNF signaling in PM2. 5-induced neurodevelopmental damage to the hippocampal neurons of rats

J Liu, B Liu, P Yuan, L Cheng, H Sun, J Gui… - Ecotoxicology and …, 2021 - Elsevier
Exposure to fine particulate matter (PM2. 5) is implicated in neurodevelopmental disorders
including cognitive decline, attention-deficit/hyperactivity disorder, and autism spectrum …

Macrophages treated with particulate matter PM2.5 induce selective neurotoxicity through glutaminase‐mediated glutamate generation

F Liu, Y Huang, F Zhang, Q Chen, B Wu… - Journal of …, 2015 - Wiley Online Library
Exposure to atmospheric particulate matter PM 2.5 (aerodynamic diameter≤ 2.5 μm) has
been epidemiologically associated with respiratory illnesses. However, recent data have …

Traffic-related air pollution impact on mouse brain accelerates myelin and neuritic aging changes with specificity for CA1 neurons

NC Woodward, P Pakbin, A Saffari… - Neurobiology of …, 2017 - Elsevier
Traffic-related air pollution (TRAP) is associated with lower cognition and reduced white
matter volume in older adults, specifically for particulate matter< 2.5-μm diameter (PM 2.5) …

[HTML][HTML] The emerging risk of exposure to air pollution on cognitive decline and Alzheimer's disease–evidence from epidemiological and animal studies

J Kilian, M Kitazawa - Biomedical journal, 2018 - Elsevier
As incidence of Alzheimer's disease (AD) and other neurodegenerative diseases rise, there
is increasing interest in environmental factors which may contribute to disease onset and …

[HTML][HTML] NF-κB-regulated microRNA-574-5p underlies synaptic and cognitive impairment in response to atmospheric PM2.5 aspiration

T Ku, B Li, R Gao, Y Zhang, W Yan, X Ji, G Li… - Particle and fibre …, 2017 - Springer
Abstract Background PM 2.5 (particulate matter≤ 2.5 μm) is one of the leading
environmental risk factors for the global burden of disease. Whereas increasing evidence …

Hippocampal inflammation and oxidative stress following exposure to diesel exhaust nanoparticles in male and female mice

M Ehsanifar, Z Montazeri, MA Taheri, M Rafati… - Neurochemistry …, 2021 - Elsevier
Air pollution exposure is among the most prevalent reasons for environmentally-induced
oxidative stress and inflammation, both of which are involved in the development and …

[HTML][HTML] Ambient air pollution increases the risk of cerebrovascular and neuropsychiatric disorders through induction of inflammation and oxidative stress

O Hahad, J Lelieveld, F Birklein, K Lieb… - International journal of …, 2020 - mdpi.com
Exposure to ambient air pollution is a well-established determinant of health and disease.
The Lancet Commission on pollution and health concludes that air pollution is the leading …

Traffic-related air pollutants (TRAP-PM) promote neuronal amyloidogenesis through oxidative damage to lipid rafts

M Cacciottolo, TE Morgan, AA Saffari… - Free Radical Biology …, 2020 - Elsevier
Traffic-related air pollution particulate matter (TRAP-PM) is associated with increased risk of
Alzheimer Disease (AD). Rodent models respond to nano-sized TRAP-PM (nPM) with …