[HTML][HTML] Multiple elements in the c-fos protein-coding region facilitate mRNA deadenylation and decay by a mechanism coupled to translation.
SC Schiavi, CL Wellington, AB Shyu, CY Chen… - Journal of biological …, 1994 - Elsevier
The c-fos proto-oncogene transcript is one of the most labile mammalian mRNAs known.
Rapid degradation of c-fos mRNA is mediated by both the c-fos protein-coding region and …
Rapid degradation of c-fos mRNA is mediated by both the c-fos protein-coding region and …
The Destabilizing Elements in the Coding Region of c-fos mRNA Are Recognized as RNA
CL Wellington, ME Greenberg… - Molecular and Cellular …, 1993 - Taylor & Francis
The protein-coding region of the c-fos proto-oncogene transcript contains elements that
direct the rapid deadenylation and decay of this mRNA in mammalian cells. The function of …
direct the rapid deadenylation and decay of this mRNA in mammalian cells. The function of …
Deadenylylation: a mechanism controlling c-fos mRNA decay
ME Greenberg, AB Shyu, JG Belasco - Enzyme, 1990 - karger.com
The c-fos proto-oncogene mRNA is extremely labile and is rapidly degraded within minutes
after being transported to the cytoplasm of growth factor-stimulated fibroblasts. Analysis of …
after being transported to the cytoplasm of growth factor-stimulated fibroblasts. Analysis of …
Two distinct destabilizing elements in the c-fos message trigger deadenylation as a first step in rapid mRNA decay.
AB Shyu, JG Belasco, ME Greenberg - Genes & development, 1991 - genesdev.cshlp.org
The mechanisms by which c-fos mRNA is targeted for decay have been examined. Rapid
removal of the poly (A) tail occurs before the transcribed portion of the c-fos message is …
removal of the poly (A) tail occurs before the transcribed portion of the c-fos message is …
The c-fos transcript is targeted for rapid decay by two distinct mRNA degradation pathways.
AB Shyu, ME Greenberg, JG Belasco - Genes & development, 1989 - genesdev.cshlp.org
Rapid degradation of c-fos proto-oncogene mRNA is crucial for transient c-fos gene
expression. Experiments were performed to investigate the cellular mechanisms responsible …
expression. Experiments were performed to investigate the cellular mechanisms responsible …
Removal of an mRNA destabilizing element correlates with the increased oncogenicity of proto-oncogene fos.
V Raymond, JA Atwater, IM Verma - Oncogene research, 1989 - europepmc.org
AU-sequence motifs present in the 3'untranslated region (UTR) of many rapidly inducible
messenger RNAs have been proposed to mediate their selective degradation. We have …
messenger RNAs have been proposed to mediate their selective degradation. We have …
U-Rich Sequence-Binding Proteins (URBPs) Interacting with a 20-Nucleotide U-Rich Sequence in the 3′ Untranslated Region of c-fos mRNA May Be Involved in the First Step …
Y You, CYA Chen, AB Shyu - Molecular and cellular biology, 1992 - Taylor & Francis
Rapid decay of the c-fos transcript plays a critical role in controlling transforming potential of
the c-fos proto-oncogene. One of the mRNA instability determinants is a 75-nucleotide AU …
the c-fos proto-oncogene. One of the mRNA instability determinants is a 75-nucleotide AU …
Interplay of two functionally and structurally distinct domains of the c-fos AU-rich element specifies its mRNA-destabilizing function
CY Chen, TM Chen, AB Shyu - Molecular and Cellular Biology, 1994 - Am Soc Microbiol
AU-rich elements (ARE) in the 3′ untranslated region of many highly labile mRNAs for
proto-oncogenes, lymphokines, and cytokines can act as an RNA-destabilizing element. The …
proto-oncogenes, lymphokines, and cytokines can act as an RNA-destabilizing element. The …
c-fos mRNA instability determinants present within both the coding and the 3'non coding region link the degradation of this mRNA to its translation.
JL Veyrune, S Carillo, A Vié, JM Blanchard - Oncogene, 1995 - europepmc.org
The instability of oncogenic mRNA such as c-fos mRNA is controlled in cis by sequences
present in both the coding and the 3'untranslated regions (3'UTR). The latter contains AU …
present in both the coding and the 3'untranslated regions (3'UTR). The latter contains AU …
Two cellular proteins bind specifically to a purine-rich sequence necessary for the destabilization function of a c-fos protein-coding region determinant of mRNA …
CYA Chen, Y You, AB Shyu - Molecular and cellular biology, 1992 - Taylor & Francis
The c-ffos proto-oncogene mRNA is rapidly degraded within minutes after its appearance in
the cytoplasm of growth factor-stimulated mammalian fibroblasts. At least two functionally …
the cytoplasm of growth factor-stimulated mammalian fibroblasts. At least two functionally …