One major determinant of rapid mRNA decay is the presence of AU-rich sequences located
in 3′ untranslated regions (UTR). To assess for the contribution of upstream sequences on …

Abstract mRNA turnover mediated by the major protein-coding-region determinant of
instability (mCRD) of the c-fos proto-oncogene transcript illustrates a functional interplay …

The transient induction of c-fos mRNA and protein suggests that regulation occurs not only
by transcriptional activation but also at the level of turnover of the gene product. Here we …

The c-fos proto-oncogene provides a good system to study the processes underlying
messenger RNA degradation. After growth factor stimulation of susceptible cells, the c-fos …

The different 3′ noncoding AU-rich elements (ARE) that mediate the degradation of many
short-lived mRNAs may function through distinct decay pathways; translation-dependent …

Poly (A) tail removal is a critical first step in the decay pathway for many yeast and
mammalian mRNAs. Poly (A) shortening rates can be regulated by cis-acting sequences …

The presence of a localization signal in the 3′-untranslated region of c-fos mRNA was
investigated by in situ hybridization and cell fractionation techniques. Cells were transfected …

The metabolic lifetime of mRNA can be specified by specific cis-acting elements within
mRNA. One type of element is an adenylate-and uridylate-rich element (ARE) found in the …

The mRNAs of transiently expressed genes frequently contain an AU-rich sequence in the
B'untranslated region. We introduced a 51 nucleotide AT sequence from a human …

Messenger RNA decay mediated by the c-fos major protein coding-region determinant of
instability (mCRD) is a useful system for studying translationally coupled mRNA turnover …