Abstract PARN, a poly (A)-specific ribonuclease, binds the 5′ cap-structure of mRNA and
initiates deadenylation-dependent decay. Eukaryotic initiation factor 4E (eIF4E) also binds to …

c-Fos proto-oncoprotein defines a family of closely related transcription factors (Fos proteins)
also comprising Fra-1, Fra-2, FosB and ΔFosB, the latter two proteins being generated by …

The 5'RNA cap structure (m7GpppRNA) is a key feature of eukaryotic mRNAs with important
roles in stability, splicing, polyadenylation, mRNA export, and translation. Higher eukaryotes …

The properties of the viral and cellular fos proteins (Fos) were investigated as a first step
toward understanding the function of the fos gene. Treatment of nuclei with salt and nonionic …

As an undergraduate at Cambridge I intended to study chemistry, but took a cell and
molecular biology course as well. I realized that the molecular basis of life is really chemistry …

An important first step in the chromatin remodelling process is the initial binding of a
transcriptional activator to a nucleosomal template. We have investigated the ability of …

Antisense RNA complementary to c-fos mRNA was produced in mouse 3T3 cells by gene
transfer techniques. Transcriptional units were constructed consisting of a steroid-inducible …

To identify functionally important domains in the fos gene product we have studied the
evolutionary divergence between chicken and mammalian fos proteins. A cDNA containing …

The transcription factor ΔFosB, a truncated splice isoform of FosB, accumulates in brain after
several types of chronic stimulation. This accumulation is thought to be mediated by the …

Several observations in eukaryotic cells suggest that the processes of translation and mRNA
turnover are interrelated. To understand this relationship, we examined the effects of …