We examined the specificity of three automated digoxin immunoassays (Abbott TDxFLx
Digoxin II assay, Baxter-Dade Stratus II Digoxin assay, and Ciba Corning ACS Digoxin …

Digoxin-like immunoreactive substance (DLIS) is known to interfere with fluorescence
polarization immunoassay (FPIA)(Digoxin II, Abbott Laboratories) and falsely elevates the …

We have examined the current state of interference by digoxin-like immunoreactive
substance (s)(DLIS) in 10 commercially available digoxin assay methods, ie 5 …

Digoxin metabolites cross-react in the Ciba Corning ACS digoxin assay in proportion to their
bioactivity, but have greater (near 100%) cross-reactivity in the Abbott TDx, Baxter Stratus …

Background: A case of digoxin toxicity resulted from falsely low values with the MEIA II assay
for digoxin (AxSYM®; Abbott). The low results were caused by negative interference from …

Measurement of unbound digoxin in presence of Fab fragments may be useful in
management of overdoses. The analysis can be performed on serum directly or on …

Six commercial digoxin immunoassay kits were evaluated for their accuracy of calibration
and their extent of interference by digoxinlike immunoreactive substance (DLIS). Calibration …

The in vivo digoxin binding affinity and normal pharmacokinetic values of digoxin-immune
Fab are unknown. Healthy subjects (n= 16) were randomized to one of the two digoxin …

Spironolactone, which is metabolized to canrenone, is often used in combination with
digoxin. Potassium canrenoate is a similar drug that is also metabolized to canrenone. As a …

Digoxin, a commonly prescribed cardiac glycoside with a narrow therapeutic window, is
routinely used in pharmacokinetic studies to assess the in vivo activity of the drug efflux …