The low-range sensitivity of a drug assay in routine use is an important aspect of that assay's
clinical usefulness. We define three concepts for determining low range sensitivity: LC, the …

Drugs and xenobiotics can affect clinical laboratory test results either by interfering with the
analytical systems themselves, or by influencing endogenous constituents. National and …

Methods for the determination of cardiovascular drugs in blood and plasma are critically
reviewed with emphasis on gas and liquid chromatographic techniques. The importance of …

Plasma concentration monitoring of antiarrhythmic agents is valuable, but it is often misused
or overemphasized in therapeutic decision-making. There are strict requirements for its …

Genetic engineering of beta-galactosidase (EC 3.2. 1.23) has led to the development of a
new homogeneous assay system, CEDIA. The Z gene of the lac operon of Escherichia coli …

Immunoassay techniques have been widely used for therapeutic drug monitoring, but lack of
antibody specificity can lead to measurement of erroneous drug concentrations due to cross …

INTRODUCTION: Digoxin is a cardiac glycoside, used to control rapid ventricular rates in
atrial fibrillation and to reduce the hospitalizations due to heart failure. Digoxin has a narrow …

Drug interactions with digoxin are important because of this agent's narrow therapeutic
index. Among the drugs that can decrease digoxin bioavailability are cholestyramine …

Serum drug concentration monitoring can be an invaluable aid to patient management,
particularly in certain pathological conditions when individualisation of dosage is particularly …

Despite recent advances in understanding of the pharmacokinetics and electrophysiologic
effects of cardiac glycosides, digitalis toxicity remains distressingly common in clinical …