Fibroblasts as efficient antigen-presenting cells in lymphoid organs

TM Kündig, MF Bachmann, C DiPaolo, JJL Simard… - Science, 1995 - science.org
Only so-called" professional" antigen-presenting cells (APCs) of hematopoietic origin are
believed capable of inducing T lymphocyte responses. However, fibroblasts transfected with …

Identifying strategies for immune intervention

A Lanzavecchia - Science, 1993 - science.org
In recent years the molecular basis of antigen recognition by T cells has been unraveled and
the various pathways that control T cell activation and functional specialization have been …

Immune response in vitro: independence of" activated" lymphoid cells

CW Pierce, B Benacerraf - Science, 1969 - science.org
Antibody formation against sheep erythrocytes by mouse spleen cells in vitro requires
interactions among antigen-treated macrophages and lymphoid cells in cell clusters for only …

Cytoplasmic interaction between macrophages and lymphocytic cells in antibody synthesis

MD Schoenberg, VR Mumaw, RD Moore… - Science, 1964 - science.org
Lymphocytic Cells in Antibody Synthesis Page 1 Based on theapproved standards for
maple syrup, sap is concentrated by evaporating the water until a specific gravity of the …

Specificity of allogeneic cell recognition by human lymphocytes in vitro

DC Zoschke, FH Bach - Science, 1971 - science.org
Human lymphocytes proliferate in vitro in response to foreign histocompatibility antigens that
are present on allogeneic lymphocytes. Within a population of immunocompetent …

Induction of Neonatal Tolerance to Mlsa Antigens by CD8+ T Cells

SR Webb, J Sprent - Science, 1990 - science.org
Antigen-specific tolerance of T cells to minor lymphocyte stimulatory (Mls) antigens can be
induced in mice by neonatal injection of foreign lymphohematopoietic cells. Although …

The ins and outs of body surface immunology

A Hayday, JL Viney - Science, 2000 - science.org
Rather than being confined to the secondary lymphoid tissue of the spleen and lymph
nodes, large numbers of lymphocytes are intrinsically associated with the epithelial surfaces …

Differing lymphokine profiles of functional subsets of human CD4 and CD8 T cell clones

P Salgame, JS Abrams, C Clayberger, H Goldstein… - Science, 1991 - science.org
Functional subsets of human T cells were delineated by analyzing patterns of lymphokines
produced by clones from individuals with leprosy and by T cell clones of known function …

Restoration of viral immunity in immunodeficient humans by the adoptive transfer of T cell clones

SR Riddell, KS Watanabe, JM Goodrich, CR Li… - Science, 1992 - science.org
The adoptive transfer of antigen-specific T cells to establish immunity is an effective therapy
for viral infections and tumors in animal models. The application of this approach to human …

Organ-resident, nonlymphoid cells suppress proliferation of autoimmune T-helper lymphocytes

RR Caspi, FG Roberge, RB Nussenblatt - Science, 1987 - science.org
Local presentation of autoantigen by organ-resident cells inappropriately expressing Ia
determinants has been implicated in organ-specific autoimmunity. Experimental …